Casdin Capital Portfolio
Casdin Capital 13F filer (CIK 0001534261).
Q2 2026 · 42 positions · Total reported value $2.00B · Top-10 concentration 77.4%
Turnover: 24.4% · 5 new · 3 cut · 3 exited
Active Share (vs S&P 500): 99.8% · vs QQQ: 99.9% — share of the book that differs from index weights (higher = more active) · ranking
In its Q2 2026 13F filing, Casdin Capital disclosed 42 equity positions with a combined reported value of $2.00B. The filing implies a focused portfolio: its ten largest positions account for 77.4% of reported value. HoldingsHub classifies the profile as Mid / Focused / Health Tilt / High Turnover.
The largest disclosed positions as of Q2 2026 were RVMD ($482.68M), RLAY ($300.02M), WGS ($254.50M). By sector, the heaviest allocations are Health Care 94.3%, Industrials 5.7%. Versus the prior quarter, allocation shifted toward Health Care (+5.2pp) and away from Technology (-1.0pp), Industrials (-4.2pp).
Versus the prior quarter, Casdin Capital opened 5 new positions, trimmed 3 and fully exited 3, a turnover rate of 24.4% of positions. The portfolio's overlap with the prior quarter was 82% of names.
Figures come from the fund's SEC Form 13F filing. 13F reports are filed within 45 days of quarter end and cover long positions of $100,000 or more; they exclude short positions and non-13F asset classes, so treat this page as a quarter-end snapshot rather than the fund's live book.
| # | Symbol | Company | Shares | Value | Weight | Change |
|---|---|---|---|---|---|---|
| 1 | RVMD | REVOLUTION MEDICINES INC | 2.58M | $482.68M | 24.18% | Hold |
| 2 | RLAY | RELAY THERAPEUTICS INC | 16.04M | $300.02M | 15.03% | Add |
| 3 | WGS | GENEDX HOLDINGS CORP | 3.71M | $254.50M | 12.75% | Add |
| 4 | BLFS | BIOLIFE SOLUTIONS INC | 4.66M | $131.46M | 6.58% | Reduce |
| 5 | ILMN | ILLUMINA INC | 530.00K | $93.19M | 4.67% | Hold |
| 6 | LAB | STANDARD BIOTOOLS INC | 88.78M | $73.04M | 3.66% | Hold |
| 7 | GPCR | STRUCTURE THERAPEUTICS INC | 1.18M | $63.06M | 3.16% | Hold |
| 8 | DNLI | DENALI THERAPEUTICS INC | 2.04M | $52.60M | 2.63% | Add |
| 9 | NGNE | NEUROGENE INC | 1.55M | $48.60M | 2.43% | Add |
| 10 | BEAM | BEAM THERAPEUTICS INC | 1.35M | $46.33M | 2.32% | Hold |
| 11 | TXG | 10X GENOMICS INC | 1.05M | $40.26M | 2.02% | Reduce |
| 12 | SRRK | SCHOLAR ROCK HLDG CORP | 665.00K | $36.58M | 1.83% | Add |
| 13 | PSNL | PERSONALIS INC | 2.55M | $34.17M | 1.71% | Add |
| 14 | GRAL | GRAIL INC | 480.00K | $32.77M | 1.64% | Add |
| 15 | GH | GUARDANT HEALTH INC | 185.00K | $27.76M | 1.39% | Reduce |
| 16 | MAZE | MAZE THERAPEUTICS INC | 843.86K | $25.18M | 1.26% | Add |
| 17 | HIMS | HIMS & HERS HEALTH INC | 700.00K | $24.27M | 1.22% | Hold |
| 18 | ALNY | ALNYLAM PHARMACEUTICALS INC | 75.00K | $22.58M | 1.13% | Hold |
| 19 | TSHA | TAYSHA GENE THERAPIES INC | 3.25M | $22.13M | 1.11% | Hold |
| 20 | AGMB | AGOMAB THERAPEUTICS NV | 1.55M | $20.12M | 1.01% | Hold |
| 21 | SEPN | SEPTERNA INC | 553.27K | $18.53M | 0.93% | Hold |
| 22 | PBLS | PARABILIS MEDICINES INC | 645.69K | $17.67M | 0.89% | New |
| 23 | SION | SIONNA THERAPEUTICS INC | 400.00K | $17.60M | 0.88% | New |
| 24 | VCYT | VERACYTE INC | 276.31K | $16.23M | 0.81% | Hold |
| 25 | ANL | ADLAI NORTYE LTD | 1.25M | $14.38M | 0.72% | Add |
| 26 | PRME | PRIME MEDICINE INC | 3.17M | $11.69M | 0.58% | Hold |
| 27 | ABSI | ABSCI CORPORATION | 973.26K | $11.28M | 0.56% | Hold |
| 28 | DGX | QUEST DIAGNOSTICS INCORPORATED | 50.00K | $10.60M | 0.53% | Hold |
| 29 | SRPT | SAREPTA THERAPEUTICS INC | 470.00K | $8.45M | 0.42% | New |
| 30 | QURE | UNIQURE NV | 150.00K | $6.91M | 0.35% | New |
| 31 | NTLA | INTELLIA THERAPEUTICS INC | 355.00K | $6.01M | 0.30% | Hold |
| 32 | MRNA | MODERNA INC | 75.00K | $5.25M | 0.26% | Hold |
| 33 | IRON | DISC MEDICINE INC | 65.00K | $4.75M | 0.24% | Hold |
| 34 | GLUE | MONTE ROSA THERAPEUTICS INC | 186.01K | $4.50M | 0.23% | Hold |
| 35 | IPSC | CENTURY THERAPEUTICS INC | 1.23M | $3.01M | 0.15% | Hold |
| 36 | CTNM | CONTINEUM THERAPEUTICS INC | 148.33K | $2.43M | 0.12% | Hold |
| 37 | BBOT | BRIDGEBIO ONCOLOGY THERAPEUT | 282.31K | $2.15M | 0.11% | Hold |
| 38 | EDIT | EDITAS MEDICINE INC | 445.00K | $1.44M | 0.07% | New |
| 39 | PACB | PACIFIC BIOSCIENCES CALIF IN | 723.77K | $1.22M | 0.06% | Hold |
| 40 | RXRX | RECURSION PHARMACEUTICALS IN | 165.32K | $606.74K | 0.03% | Hold |
| 41 | DNA | GINKGO BIOWORKS HOLDINGS INC | 36.49K | $361.65K | 0.02% | Hold |
| 42 | TNYA | TENAYA THERAPEUTICS INC | 361.97K | $267.53K | 0.01% | Hold |