SYRE — SPYRE THERAPEUTICS INC
Reported value held$3.56B
Funds holding (latest)40
SectorHealth Care
Funds holding (Q2 2026)33
Institutional value$3.31B · 40.06M sh
New / Add / Cut / Exit5 / 25 / 3 / 1
Top-5 / Top-10 concentration70.7% / 88.5%
Institutional holdings change
Accumulating +31.7%
(+9.64M sh)
Institutional value change
Up +127.5%
As of Q2 2026, 33 SEC-registered investment managers reported holding SYRE (SPYRE THERAPEUTICS INC) in their latest 13F filings, with a combined reported value of $3.31B across 40.06M shares. That is +31.7% by share count (+9.64M shares) versus the previous quarter, while reported value moved +127.5%. Ownership is concentrated: the five largest holders account for 70.7% of reported value and the top ten for 88.5%.
Compared with the prior quarter, 5 opened new positions, 25 added to existing stakes, 3 trimmed, 1 exited entirely. 13F holdings are quarter-end snapshots, so these moves reflect positioning as of Q2 2026, not real-time trading.
SYRE is classified in the Health Care sector.
All figures on this page are computed from SEC Form 13F quarterly filings. 13F filers disclose long positions of $100,000 or more within 45 days of quarter end; short positions, options overlays and intra-quarter trades are not included, so treat the numbers as a quarterly snapshot of institutional ownership rather than real-time positioning.
Q2 2026 — 33 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 13.03M | $1.16B | 0.06% | Add |
| BlackRock Inc history | 6.51M | $577.66M | 0.01% | Add |
| Geode Capital Management history | 2.56M | $239.26M | 0.01% | Add |
| Capital World Investors history | 2.32M | $205.57M | 0.03% | Add |
| Bank of America Corp history | 1.78M | $157.84M | 0.01% | Add |
| Wellington Management Group history | 1.58M | $140.41M | 0.03% | Reduce |
| Goldman Sachs Group history | 1.48M | $131.22M | 0.01% | Add |
| Franklin Resources history | 1.47M | $130.77M | 0.03% | Add |
| JPMorgan Chase & Co history | 1.09M | $98.87M | 0.01% | New |
| Marshall Wace history | 991.69K | $88.04M | 0.07% | Add |
| UBS Group AG history | 843.07K | $74.85M | 0.01% | Add |
| Northern Trust Corp history | 674.53K | $59.88M | 0.01% | Add |
| Charles Schwab Investment Management history | 652.96K | $57.97M | 0.01% | Add |
| Morgan Stanley history | 499.96K | $44.39M | 0.00% | Add |
| BNY Mellon history | 245.19K | $21.77M | 0.00% | Add |
| Millennium Management history | 196.71K | $17.46M | 0.01% | Add |
| Deutsche Bank AG history | 174.46K | $15.49M | 0.01% | Add |
| Citadel Advisors history | 154.80K | $13.74M | 0.00% | Add |
| Balyasny Asset Management history | 147.04K | $13.05M | 0.02% | Add |
| Invesco Ltd history | 120.54K | $10.70M | 0.00% | Reduce |
| Manulife Financial history | 104.52K | $9.28M | 0.01% | Reduce |
| Prudential Financial history | 87.37K | $7.76M | 0.01% | Add |
| Citigroup Inc history | 82.59K | $7.33M | 0.00% | Add |
| Wells Fargo & Co history | 82.51K | $7.32M | 0.00% | Add |
| Principal Global Investors history | 59.75K | $5.30M | 0.00% | Add |
| Royce & Associates history | 51.79K | $4.60M | 0.04% | New |
| Legal & General Investment Management America history | 49.14K | $4.36M | 0.00% | Add |
| D. E. Shaw & Co history | 26.45K | $2.35M | 0.00% | New |
| AQR Capital Management history | 22.94K | $2.04M | 0.00% | Add |
| Two Sigma Investments history | 12.77K | $1.13M | 0.00% | New |
| T. Rowe Price Associates history | 2.96M | $262.87K | 0.03% | Add |
| Amundi US history | 2.79K | $247.96K | 0.00% | New |
| PNC Financial Services history | 914 | $81.14K | 0.00% | Add |
Q1 2026 — 29 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 11.78M | $594.23M | 0.03% | Add |
| BlackRock Inc history | 5.52M | $278.49M | 0.01% | Hold |
| Wellington Management Group history | 1.82M | $92.04M | 0.02% | Add |
| Geode Capital Management history | 1.72M | $86.82M | 0.01% | Add |
| Janus Henderson Group history | 1.66M | $83.59M | 0.04% | Reduce |
| Bank of America Corp history | 1.23M | $61.95M | 0.01% | Add |
| Franklin Resources history | 882.83K | $44.53M | 0.01% | Reduce |
| UBS Group AG history | 671.24K | $33.86M | 0.01% | Reduce |
| Capital World Investors history | 666.56K | $33.62M | 0.01% | Add |
| Northern Trust Corp history | 578.91K | $29.20M | 0.00% | Add |
| Charles Schwab Investment Management history | 562.65K | $28.38M | 0.00% | Reduce |
| Goldman Sachs Group history | 269.94K | $13.62M | 0.00% | Reduce |
| Morgan Stanley history | 246.72K | $12.44M | 0.00% | Add |
| BNY Mellon history | 191.40K | $9.65M | 0.00% | Reduce |
| Millennium Management history | 146.64K | $7.40M | 0.00% | Add |
| Marshall Wace history | 139.26K | $7.02M | 0.01% | New |
| Invesco Ltd history | 132.39K | $6.68M | 0.00% | Reduce |
| Deutsche Bank AG history | 129.24K | $6.52M | 0.00% | Add |
| Citadel Advisors history | 123.44K | $6.23M | 0.00% | Add |
| Manulife Financial history | 112.84K | $5.69M | 0.01% | Reduce |
| Prudential Financial history | 59.55K | $3.00M | 0.00% | New |
| Balyasny Asset Management history | 55.48K | $2.80M | 0.00% | Reduce |
| Legal & General Investment Management America history | 44.79K | $2.26M | 0.00% | Reduce |
| Wells Fargo & Co history | 33.21K | $1.68M | 0.00% | Reduce |
| AQR Capital Management history | 20.87K | $1.05M | 0.00% | Add |
| Citigroup Inc history | 12.01K | $605.58K | 0.00% | Reduce |
| Principal Global Investors history | 4.30K | $216.84K | 0.00% | New |
| T. Rowe Price Associates history | 1.60M | $80.64K | 0.01% | Hold |
| PNC Financial Services history | 123 | $6.20K | 0.00% | Add |
Q4 2025 — 29 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 11.64M | $381.29M | 0.02% | Add |
| BlackRock Inc history | 5.52M | $180.90M | 0.00% | Add |
| Vanguard Group history | 4.04M | $132.19M | 0.00% | Add |
| Janus Henderson Group history | 1.83M | $59.92M | 0.03% | Add |
| Geode Capital Management history | 1.66M | $54.36M | 0.00% | Add |
| Wellington Management Group history | 1.55M | $50.75M | 0.01% | Reduce |
| Franklin Resources history | 1.11M | $36.34M | 0.01% | Add |
| UBS Group AG history | 680.57K | $22.30M | 0.00% | Add |
| Point72 Asset Management history | 662.35K | $21.70M | 0.03% | New |
| Charles Schwab Investment Management history | 574.62K | $18.82M | 0.00% | Add |
| Northern Trust Corp history | 561.02K | $18.38M | 0.00% | Add |
| Bank of America Corp history | 419.73K | $13.75M | 0.00% | Add |
| Goldman Sachs Group history | 275.06K | $9.01M | 0.00% | Reduce |
| Capital World Investors history | 200.17K | $6.56M | 0.00% | Hold |
| BNY Mellon history | 192.83K | $6.32M | 0.00% | Add |
| Morgan Stanley history | 182.73K | $5.99M | 0.00% | Reduce |
| Invesco Ltd history | 150.93K | $4.94M | 0.00% | Add |
| Manulife Financial history | 129.01K | $4.14M | 0.00% | Add |
| Deutsche Bank AG history | 121.94K | $3.99M | 0.00% | Add |
| Citigroup Inc history | 100.06K | $3.28M | 0.00% | Add |
| Citadel Advisors history | 88.80K | $2.91M | 0.00% | New |
| Wells Fargo & Co history | 82.42K | $2.70M | 0.00% | Add |
| Millennium Management history | 76.19K | $2.50M | 0.00% | Reduce |
| Balyasny Asset Management history | 73.47K | $2.41M | 0.00% | New |
| JPMorgan Chase & Co history | 62.95K | $2.06M | 0.00% | Reduce |
| Legal & General Investment Management America history | 56.45K | $1.85M | 0.00% | Add |
| AQR Capital Management history | 17.82K | $583.78K | 0.00% | Add |
| T. Rowe Price Associates history | 1.60M | $52.48K | 0.01% | Add |
| PNC Financial Services history | 86 | $2.82K | 0.00% | Hold |
Q3 2025 — 26 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 9.06M | $151.85M | 0.01% | Hold |
| BlackRock Inc history | 3.98M | $66.75M | 0.00% | Reduce |
| Vanguard Group history | 3.05M | $51.13M | 0.00% | Reduce |
| Wellington Management Group history | 1.64M | $27.49M | 0.01% | Add |
| Geode Capital Management history | 1.23M | $20.54M | 0.00% | Hold |
| Franklin Resources history | 795.27K | $13.33M | 0.00% | Hold |
| Northern Trust Corp history | 442.04K | $7.41M | 0.00% | Add |
| Charles Schwab Investment Management history | 425.35K | $7.13M | 0.00% | Add |
| Millennium Management history | 408.20K | $6.84M | 0.00% | New |
| UBS Group AG history | 385.59K | $6.46M | 0.00% | Reduce |
| Bank of America Corp history | 344.80K | $5.78M | 0.00% | Reduce |
| Morgan Stanley history | 334.72K | $5.61M | 0.00% | Reduce |
| Goldman Sachs Group history | 329.53K | $5.52M | 0.00% | Reduce |
| JPMorgan Chase & Co history | 275.98K | $4.63M | 0.00% | Add |
| Capital World Investors history | 200.17K | $3.35M | 0.00% | Reduce |
| BNY Mellon history | 135.96K | $2.28M | 0.00% | Add |
| Manulife Financial history | 71.95K | $1.21M | 0.00% | Reduce |
| Invesco Ltd history | 50.70K | $849.76K | 0.00% | Add |
| Legal & General Investment Management America history | 46.84K | $785.05K | 0.00% | Add |
| Wells Fargo & Co history | 39.32K | $658.99K | 0.00% | Add |
| Deutsche Bank AG history | 38.54K | $645.98K | 0.00% | Add |
| Citigroup Inc history | 32.90K | $551.34K | 0.00% | Add |
| AQR Capital Management history | 17.05K | $285.71K | 0.00% | Reduce |
| Janus Henderson Group history | 13.00K | $217.94K | 0.00% | Hold |
| T. Rowe Price Associates history | 620.62K | $10.40K | 0.00% | Reduce |
| PNC Financial Services history | 86 | $1.44K | 0.00% | New |
Q2 2025 — 25 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 9.05M | $135.52M | 0.01% | Hold |
| BlackRock Inc history | 4.01M | $59.99M | 0.00% | Add |
| Vanguard Group history | 3.07M | $45.91M | 0.00% | Add |
| Wellington Management Group history | 1.51M | $22.66M | 0.00% | Reduce |
| Geode Capital Management history | 1.23M | $18.37M | 0.00% | Add |
| Franklin Resources history | 795.27K | $11.91M | 0.00% | Add |
| Morgan Stanley history | 671.04K | $10.05M | 0.00% | Add |
| Goldman Sachs Group history | 523.42K | $7.84M | 0.00% | Add |
| UBS Group AG history | 462.86K | $6.93M | 0.00% | Reduce |
| Northern Trust Corp history | 436.95K | $6.54M | 0.00% | Add |
| Charles Schwab Investment Management history | 418.50K | $6.26M | 0.00% | Add |
| Bank of America Corp history | 396.35K | $5.93M | 0.00% | Reduce |
| Capital World Investors history | 350.77K | $5.25M | 0.00% | Hold |
| BNY Mellon history | 132.15K | $1.98M | 0.00% | Add |
| Manulife Financial history | 79.90K | $1.20M | 0.00% | Add |
| JPMorgan Chase & Co history | 47.28K | $707.77K | 0.00% | Add |
| Legal & General Investment Management America history | 34.97K | $523.49K | 0.00% | Reduce |
| Invesco Ltd history | 34.68K | $519.16K | 0.00% | Add |
| Wells Fargo & Co history | 34.41K | $515.10K | 0.00% | Add |
| Deutsche Bank AG history | 33.94K | $508.05K | 0.00% | Add |
| Renaissance Technologies history | 30.94K | $463.11K | 0.00% | New |
| Citigroup Inc history | 29.26K | $438.04K | 0.00% | Reduce |
| AQR Capital Management history | 17.97K | $269.06K | 0.00% | New |
| Janus Henderson Group history | 13.00K | $194.48K | 0.00% | Reduce |
| T. Rowe Price Associates history | 930.48K | $13.93K | 0.00% | Add |
Q1 2025 — 26 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 9.04M | $145.84M | 0.01% | Add |
| BlackRock Inc history | 3.57M | $57.65M | 0.00% | Add |
| Vanguard Group history | 2.90M | $46.76M | 0.00% | Add |
| Wellington Management Group history | 1.59M | $25.71M | 0.01% | Reduce |
| Janus Henderson Group history | 1.04M | $18.68M | 0.01% | Reduce |
| Geode Capital Management history | 1.06M | $17.10M | 0.00% | Add |
| Franklin Resources history | 760.63K | $12.27M | 0.00% | Hold |
| UBS Group AG history | 552.24K | $8.91M | 0.00% | Add |
| Bank of America Corp history | 427.07K | $6.89M | 0.00% | Add |
| Charles Schwab Investment Management history | 382.64K | $6.17M | 0.00% | Add |
| Northern Trust Corp history | 379.88K | $6.13M | 0.00% | Add |
| Capital World Investors history | 350.77K | $5.66M | 0.00% | Reduce |
| Morgan Stanley history | 335.47K | $5.41M | 0.00% | Add |
| Goldman Sachs Group history | 197.07K | $3.18M | 0.00% | Reduce |
| Citadel Advisors history | 140.18K | $2.26M | 0.00% | Reduce |
| Soros Fund Management history | 125.00K | $2.02M | 0.03% | Reduce |
| BNY Mellon history | 114.24K | $1.84M | 0.00% | Add |
| Citigroup Inc history | 83.46K | $1.35M | 0.00% | Add |
| Manulife Financial history | 53.90K | $869.69K | 0.00% | Add |
| JPMorgan Chase & Co history | 41.56K | $670.51K | 0.00% | Add |
| Legal & General Investment Management America history | 37.84K | $610.61K | 0.00% | Add |
| Wells Fargo & Co history | 30.04K | $484.62K | 0.00% | Add |
| Deutsche Bank AG history | 28.48K | $459.72K | 0.00% | Reduce |
| Invesco Ltd history | 25.21K | $406.71K | 0.00% | Add |
| T. Rowe Price Associates history | 248.54K | $4.01K | 0.00% | Reduce |
| Amundi US history | 5 | $70 | 0.00% | Reduce |
New Positions (Q2 2026)
- JPMorgan Chase & Co 1.09M sh · $98.87M
- Royce & Associates 51.79K sh · $4.60M
- D. E. Shaw & Co 26.45K sh · $2.35M
- Two Sigma Investments 12.77K sh · $1.13M
- Amundi US 2.79K sh · $247.96K
Fully Exited (vs previous quarter)
- Janus Henderson Group sold 1.66M sh · $83.59M
Fund Position History — shares by quarter (top 20 funds)
| Fund | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fidelity Management & Research (FMR) | 13.03M | 11.78M | 11.64M | 9.06M | 9.05M | 9.04M | 8.80M | 7.62M | 7.51M | 6.58M | 3.79M | — |
| BlackRock Inc | 6.51M | 5.52M | 5.52M | 3.98M | 4.01M | 3.57M | 3.40M | 2.66M | — | — | — | — |
| Geode Capital Management | 2.56M | 1.72M | 1.66M | 1.23M | 1.23M | 1.06M | 966.13K | 891.05K | 765.83K | 330.23K | 30.33K | 26.80K |
| Capital World Investors | 2.32M | 666.56K | 200.17K | 200.17K | 350.77K | 350.77K | 378.57K | — | — | — | — | — |
| Bank of America Corp | 1.78M | 1.23M | 419.73K | 344.80K | 396.35K | 427.07K | 7.14K | 257.80K | 191.17K | 36.33K | — | — |
| Wellington Management Group | 1.58M | 1.82M | 1.55M | 1.64M | 1.51M | 1.59M | 1.60M | 1.51M | 795.95K | 812.86K | 635.46K | — |
| Goldman Sachs Group | 1.48M | 269.94K | 275.06K | 329.53K | 523.42K | 197.07K | 747.55K | 169.31K | 893.08K | 239.91K | — | — |
| Franklin Resources | 1.47M | 882.83K | 1.11M | 795.27K | 795.27K | 760.63K | 760.64K | 760.67K | 741.90K | 741.90K | 687.09K | — |
| JPMorgan Chase & Co | 1.09M | — | 62.95K | 275.98K | 47.28K | 41.56K | 35.25K | 29.47K | 22.77K | 11 | 41 | 41 |
| Marshall Wace | 991.69K | 139.26K | — | — | — | — | — | — | — | 161.92K | 20.25K | — |
| UBS Group AG | 843.07K | 671.24K | 680.57K | 385.59K | 462.86K | 552.24K | 392.20K | 57.84K | 44.50K | 2.60K | 3.73K | — |
| Northern Trust Corp | 674.53K | 578.91K | 561.02K | 442.04K | 436.95K | 379.88K | 348.98K | 314.29K | 85.59K | 66.34K | — | — |
| Charles Schwab Investment Management | 652.96K | 562.65K | 574.62K | 425.35K | 418.50K | 382.64K | 379.65K | 333.27K | 98.18K | 15.00K | — | — |
| Morgan Stanley | 499.96K | 246.72K | 182.73K | 334.72K | 671.04K | 335.47K | 255.26K | 243.74K | 408.85K | 51.19K | 40 | 46 |
| BNY Mellon | 245.19K | 191.40K | 192.83K | 135.96K | 132.15K | 114.24K | 103.69K | 104.81K | 117.69K | 6.05K | — | — |
| Millennium Management | 196.71K | 146.64K | 76.19K | 408.20K | — | — | 167.80K | — | — | 319.56K | 108.49K | 37.81K |
| Deutsche Bank AG | 174.46K | 129.24K | 121.94K | 38.54K | 33.94K | 28.48K | 31.42K | 21.51K | 16.25K | 298 | — | — |
| Citadel Advisors | 154.80K | 123.44K | 88.80K | — | — | 140.18K | 1.09M | 709.49K | 711.69K | 707.59K | 576.77K | 97.11K |
| Balyasny Asset Management | 147.04K | 55.48K | 73.47K | — | — | — | — | 227.95K | 272.64K | 32.40K | — | — |
| Invesco Ltd | 120.54K | 132.39K | 150.93K | 50.70K | 34.68K | 25.21K | 19.66K | 137.86K | 16.36K | 152.58K | — | — |
▲ Bought Low (fund opened/added, stock rose ≥5% next quarter) ▼ Sold High (fund reduced, stock fell ≥5% next quarter)
Drag / scroll to zoom · Default shows the most recent year · Annotations come from quarterly fund actions in 13F filings · Hover a marker for details