SPRO — SPERO THERAPEUTICS INC
As of Q2 2026, 19 SEC-registered investment managers reported holding SPRO (SPERO THERAPEUTICS INC) in their latest 13F filings, with a combined reported value of $8.03M across 3.63M shares. That is -6.7% by share count (-259.09K shares) versus the previous quarter, while reported value moved -11.8%. Ownership is concentrated: the five largest holders account for 77.7% of reported value and the top ten for 96.3%.
Compared with the prior quarter, 6 opened new positions, 5 added to existing stakes, 6 trimmed, 1 exited entirely. 13F holdings are quarter-end snapshots, so these moves reflect positioning as of Q2 2026, not real-time trading.
SPRO is classified in the Health Care sector.
All figures on this page are computed from SEC Form 13F quarterly filings. 13F filers disclose long positions of $100,000 or more within 45 days of quarter end; short positions, options overlays and intra-quarter trades are not included, so treat the numbers as a quarterly snapshot of institutional ownership rather than real-time positioning.
| Fund | Quarter | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|---|
| Vanguard Group history | Q4 2025 | 2.08M | $4.85M | 0.00% | Add |
| Renaissance Technologies history | Q2 2026 | 947.90K | $2.09M | 0.00% | Reduce |
| BlackRock Inc history | Q2 2026 | 594.40K | $1.31M | 0.00% | Add |
| Geode Capital Management history | Q2 2026 | 566.33K | $1.25M | 0.00% | Add |
| Two Sigma Investments history | Q2 2026 | 382.81K | $846.02K | 0.00% | Reduce |
| Arrowstreet Capital history | Q2 2026 | 332.97K | $735.86K | 0.00% | New |
| Goldman Sachs Group history | Q2 2026 | 256.99K | $567.94K | 0.00% | New |
| D. E. Shaw & Co history | Q2 2022 | 649.33K | $481.00K | 0.00% | Add |
| AQR Capital Management history | Q3 2022 | 186.68K | $373.00K | 0.00% | Add |
| Marshall Wace history | Q1 2026 | 157.07K | $367.55K | 0.00% | New |
| UBS Group AG history | Q2 2026 | 139.68K | $308.69K | 0.00% | Add |
| Northern Trust Corp history | Q2 2026 | 108.27K | $239.29K | 0.00% | Reduce |
| Point72 Asset Management history | Q2 2026 | 104.38K | $230.67K | 0.00% | Add |
| Citadel Advisors history | Q2 2026 | 65.60K | $144.98K | 0.00% | Reduce |
| Invesco Ltd history | Q2 2026 | 64.25K | $141.98K | 0.00% | Add |
| Deutsche Bank AG history | Q1 2022 | 13.88K | $121.00K | 0.00% | Reduce |
| Manulife Financial history | Q1 2022 | 11.62K | $101.00K | 0.00% | Reduce |
| Charles Schwab Investment Management history | Q2 2026 | 28.57K | $63.13K | 0.00% | Hold |
| Millennium Management history | Q2 2026 | 19.30K | $42.65K | 0.00% | New |
| Royce & Associates history | Q2 2023 | 22.85K | $33.13K | 0.00% | New |
New Positions (Q2 2026)
- Arrowstreet Capital 332.97K sh · $735.86K
- Goldman Sachs Group 256.99K sh · $567.94K
- Millennium Management 19.30K sh · $42.65K
- Prudential Financial 10.40K sh · $22.98K
- Fidelity Management & Research (FMR) 300 sh · $663
- JPMorgan Chase & Co 236 sh · $533
Fully Exited (vs previous quarter)
- Marshall Wace sold 157.07K sh · $367.55K
Fund Position History — shares by quarter (top 20 funds)
| Fund | Q3 2021 | Q4 2021 | Q1 2022 | Q2 2022 | Q3 2022 | Q4 2022 | Q1 2023 | Q2 2023 | Q3 2023 | Q4 2023 | Q1 2024 | Q2 2024 | Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Renaissance Technologies | — | — | 109.10K | 939.02K | 214.70K | 342.90K | 410.30K | 593.43K | 547.16K | 547.47K | 854.46K | 975.95K | 974.65K | 1.11M | 970.91K | 832.16K | 1.45M | 1.28M | 1.19M | 947.90K |
| BlackRock Inc | — | — | — | — | — | — | — | — | — | — | — | — | 484.82K | 485.35K | 482.08K | 434.77K | 434.77K | 433.62K | 433.20K | 594.40K |
| Geode Capital Management | 444.91K | 457.18K | 471.19K | 290.26K | 290.26K | 257.28K | 337.86K | 390.81K | 412.71K | 412.71K | 469.44K | 492.19K | 481.19K | 481.13K | 524.87K | 510.70K | 527.48K | 529.20K | 519.92K | 566.33K |
| Two Sigma Investments | — | — | 78.91K | 437.28K | — | 39.80K | 32.10K | 84.53K | 17.02K | — | — | — | — | — | — | — | 49.40K | 372.57K | 885.63K | 382.81K |
| Arrowstreet Capital | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 150.52K | — | — | 332.97K |
| Goldman Sachs Group | 137.58K | 138.61K | 141.43K | 303.20K | 55.44K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 256.99K |
| UBS Group AG | 28.82K | 33.08K | 755 | 755 | 22.91K | 45.68K | 41.52K | 27.07K | 27.14K | 329 | 5.73K | 331 | 17.53K | 141 | 2.83K | 8.19K | 27.10K | 116.45K | 3.01K | 139.68K |
| Northern Trust Corp | 257.94K | 253.20K | 238.45K | 69.97K | 69.96K | 69.58K | 86.26K | 88.75K | 88.88K | 88.88K | 114.56K | 112.30K | 111.50K | 86.45K | 100.92K | 100.83K | 129.64K | 120.98K | 120.98K | 108.27K |
| Point72 Asset Management | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 43.58K | 59.67K | 104.38K |
| Citadel Advisors | 62.80K | 43.00K | 27.60K | 185.75K | — | — | — | 15.66K | — | 32.27K | — | 313.53K | 81.83K | 173.27K | 70.72K | 240.99K | 54.80K | 470.96K | 425.66K | 65.60K |
| Invesco Ltd | — | — | — | — | — | 12.07K | 18.98K | — | — | — | — | — | — | — | — | 14.97K | 22.10K | 24.70K | 45.37K | 64.25K |
| Charles Schwab Investment Management | 63.59K | 65.55K | 65.55K | — | — | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K | 28.57K |
| Millennium Management | — | — | 61.26K | 314.64K | 688.40K | 876.40K | 494.54K | 373.85K | 119.69K | 148.86K | 147.87K | 98.52K | 32.17K | — | — | — | — | 24.11K | — | 19.30K |
| Prudential Financial | — | — | — | — | — | 14.60K | — | 24.40K | 28.20K | 28.20K | 25.40K | — | — | 49.20K | 56.00K | — | — | — | — | 10.40K |
| Citigroup Inc | 16.09K | 32.90K | 1.58K | 14.36K | 495 | — | — | — | — | — | — | — | — | — | — | — | — | 17 | 19.14K | 9.62K |
| Morgan Stanley | 56.50K | 50.48K | 73.00K | 194.43K | 19.25K | 17.08K | 15.23K | 9.53K | 8.99K | 12.04K | 7.90K | 6.97K | 6.97K | 6.97K | 6.97K | 9.22K | 43.38K | 313 | 4.55K | 914 |
| Fidelity Management & Research (FMR) | — | — | 103 | 4.12K | — | — | — | 4 | — | 189 | 2.39K | 2.89K | 3.14K | 4.29K | 5.06K | — | 550 | — | — | 300 |
| JPMorgan Chase & Co | 104.93K | 97.19K | 81.17K | 1.27K | 124.79K | 236 | 236 | 236 | 236 | 236 | 236 | 236 | 236 | 61.62K | 60.82K | 37.74K | 236 | 5.37K | — | 236 |
| Wells Fargo & Co | 7.77K | 22.69K | 14.28K | 891 | 403 | 408 | 511 | 529 | 515 | 533 | 540 | 1.00K | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 |
| Bank of America Corp | 13.67K | 41.65K | 9.81K | 18.57K | 9.78K | 7.94K | 18.42K | 13.24K | 8.78K | 5.75K | 5.19K | 5.56K | 5.65K | 5.55K | 5.57K | 5.63K | 733 | 744 | — | — |
▲ Bought Low (fund opened/added, stock rose ≥5% next quarter) ▼ Sold High (fund reduced, stock fell ≥5% next quarter)
Drag / scroll to zoom · Default shows the most recent year · Annotations come from quarterly fund actions in 13F filings · Hover a marker for details