LXRX — LEXICON PHARMACEUTICALS INC
Reported value held$247.15M
Funds holding (latest)36
SectorHealth Care
Funds holding (Q2 2026)30
Institutional value$232.18M · 96.93M sh
New / Add / Cut / Exit9 / 11 / 9 / 1
Top-5 / Top-10 concentration88.5% / 95.6%
Institutional holdings change
Accumulating +24.1%
(+18.81M sh)
Institutional value change
Up +90.5%
As of Q2 2026, 30 SEC-registered investment managers reported holding LXRX (LEXICON PHARMACEUTICALS INC) in their latest 13F filings, with a combined reported value of $232.18M across 96.93M shares. That is +24.1% by share count (+18.81M shares) versus the previous quarter, while reported value moved +90.5%. Ownership is concentrated: the five largest holders account for 88.5% of reported value and the top ten for 95.6%.
Compared with the prior quarter, 9 opened new positions, 11 added to existing stakes, 9 trimmed, 1 exited entirely. 13F holdings are quarter-end snapshots, so these moves reflect positioning as of Q2 2026, not real-time trading.
LXRX is classified in the Health Care sector.
All figures on this page are computed from SEC Form 13F quarterly filings. 13F filers disclose long positions of $100,000 or more within 45 days of quarter end; short positions, options overlays and intra-quarter trades are not included, so treat the numbers as a quarterly snapshot of institutional ownership rather than real-time positioning.
Q2 2026 — 30 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 51.78M | $124.28M | 0.01% | Add |
| BlackRock Inc history | 17.35M | $41.64M | 0.00% | Add |
| Point72 Asset Management history | 8.25M | $19.80M | 0.02% | Add |
| Geode Capital Management history | 6.24M | $14.99M | 0.00% | Add |
| Citadel Advisors history | 1.99M | $4.77M | 0.00% | Add |
| Northern Trust Corp history | 1.97M | $4.72M | 0.00% | Add |
| Charles Schwab Investment Management history | 1.96M | $4.70M | 0.00% | Add |
| Millennium Management history | 1.13M | $2.72M | 0.00% | Reduce |
| Renaissance Technologies history | 1.13M | $2.70M | 0.00% | Reduce |
| UBS Group AG history | 684.71K | $1.64M | 0.00% | Reduce |
| Two Sigma Investments history | 643.44K | $1.54M | 0.00% | Reduce |
| BNY Mellon history | 568.71K | $1.36M | 0.00% | Add |
| Invesco Ltd history | 508.07K | $1.22M | 0.00% | Reduce |
| Goldman Sachs Group history | 485.55K | $1.17M | 0.00% | Reduce |
| Bank of America Corp history | 421.30K | $1.01M | 0.00% | Reduce |
| CPP Investments history | 257.90K | $618.96K | 0.00% | New |
| Deutsche Bank AG history | 247.53K | $594.07K | 0.00% | New |
| Wells Fargo & Co history | 230.47K | $553.13K | 0.00% | Add |
| Wellington Management Group history | 179.70K | $431.28K | 0.00% | New |
| Citigroup Inc history | 175.21K | $420.49K | 0.00% | Add |
| Morgan Stanley history | 132.90K | $318.96K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 109.84K | $289.98K | 0.00% | New |
| AQR Capital Management history | 75.23K | $180.55K | 0.00% | Reduce |
| Prudential Financial history | 71.34K | $171.23K | 0.00% | Add |
| Manulife Financial history | 69.75K | $167.39K | 0.00% | New |
| Legal & General Investment Management America history | 24.18K | $58.04K | 0.00% | New |
| D. E. Shaw & Co history | 22.20K | $53.28K | 0.00% | New |
| Principal Global Investors history | 19.03K | $45.68K | 0.00% | New |
| PNC Financial Services history | 1.46K | $3.51K | 0.00% | Hold |
| T. Rowe Price Associates history | 204.39K | $491 | 0.00% | New |
Q1 2026 — 22 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 45.06M | $70.29M | 0.00% | Add |
| Point72 Asset Management history | 7.81M | $12.19M | 0.02% | Add |
| Millennium Management history | 4.94M | $7.71M | 0.00% | Add |
| BlackRock Inc history | 3.32M | $5.18M | 0.00% | Add |
| Geode Capital Management history | 3.17M | $4.95M | 0.00% | Add |
| UBS Group AG history | 2.48M | $3.87M | 0.00% | Reduce |
| Marshall Wace history | 2.38M | $3.71M | 0.00% | Add |
| Citadel Advisors history | 1.69M | $2.63M | 0.00% | Reduce |
| Renaissance Technologies history | 1.60M | $2.50M | 0.00% | Add |
| Charles Schwab Investment Management history | 1.31M | $2.05M | 0.00% | Add |
| Two Sigma Investments history | 1.20M | $1.87M | 0.00% | Add |
| Goldman Sachs Group history | 1.07M | $1.67M | 0.00% | Add |
| Bank of America Corp history | 526.10K | $820.72K | 0.00% | Add |
| Invesco Ltd history | 512.43K | $799.38K | 0.00% | Reduce |
| Northern Trust Corp history | 494.67K | $771.68K | 0.00% | Add |
| Morgan Stanley history | 219.86K | $342.99K | 0.00% | Add |
| Citigroup Inc history | 166.40K | $259.58K | 0.00% | Add |
| AQR Capital Management history | 96.23K | $150.12K | 0.00% | Reduce |
| Prudential Financial history | 33.80K | $52.73K | 0.00% | Hold |
| BNY Mellon history | 27.46K | $42.84K | 0.00% | Add |
| Wells Fargo & Co history | 7.76K | $12.11K | 0.00% | Add |
| PNC Financial Services history | 1.46K | $2.28K | 0.00% | Hold |
Q4 2025 — 24 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 37.83M | $43.51M | 0.00% | Reduce |
| Vanguard Group history | 9.61M | $11.05M | 0.00% | Add |
| Millennium Management history | 4.82M | $5.54M | 0.00% | Add |
| BlackRock Inc history | 3.19M | $3.67M | 0.00% | Reduce |
| UBS Group AG history | 3.01M | $3.46M | 0.00% | Add |
| Geode Capital Management history | 2.50M | $2.88M | 0.00% | Add |
| Citadel Advisors history | 2.27M | $2.61M | 0.00% | Reduce |
| Marshall Wace history | 1.26M | $1.45M | 0.00% | New |
| Charles Schwab Investment Management history | 1.06M | $1.21M | 0.00% | Reduce |
| Goldman Sachs Group history | 921.20K | $1.06M | 0.00% | Add |
| Two Sigma Investments history | 637.31K | $732.90K | 0.00% | Add |
| Invesco Ltd history | 594.88K | $684.12K | 0.00% | Add |
| Northern Trust Corp history | 412.16K | $473.99K | 0.00% | Add |
| Point72 Asset Management history | 284.02K | $326.63K | 0.00% | New |
| Renaissance Technologies history | 263.25K | $302.74K | 0.00% | Reduce |
| Morgan Stanley history | 193.03K | $221.99K | 0.00% | Add |
| AQR Capital Management history | 144.80K | $166.52K | 0.00% | Reduce |
| Bank of America Corp history | 102.10K | $117.41K | 0.00% | Add |
| Citigroup Inc history | 91.67K | $105.42K | 0.00% | Add |
| Prudential Financial history | 33.80K | $38.87K | 0.00% | Reduce |
| BNY Mellon history | 19.12K | $21.99K | 0.00% | Hold |
| Lazard Asset Management history | 14.09K | $16.20K | 0.00% | New |
| PNC Financial Services history | 1.46K | $1.68K | 0.00% | Hold |
| Wells Fargo & Co history | 1 | $1 | 0.00% | Reduce |
Q3 2025 — 22 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 38.68M | $52.22M | 0.00% | Add |
| Vanguard Group history | 9.52M | $12.85M | 0.00% | Add |
| Millennium Management history | 3.83M | $5.17M | 0.00% | Add |
| BlackRock Inc history | 3.39M | $4.58M | 0.00% | Add |
| Citadel Advisors history | 3.09M | $4.17M | 0.00% | Add |
| Geode Capital Management history | 2.40M | $3.24M | 0.00% | Add |
| Charles Schwab Investment Management history | 1.14M | $1.55M | 0.00% | Add |
| Two Sigma Investments history | 559.01K | $754.66K | 0.00% | Add |
| Invesco Ltd history | 521.40K | $703.89K | 0.00% | Add |
| Northern Trust Corp history | 369.79K | $499.22K | 0.00% | Reduce |
| UBS Group AG history | 352.92K | $476.44K | 0.00% | Reduce |
| AQR Capital Management history | 302.93K | $408.96K | 0.00% | Reduce |
| Renaissance Technologies history | 292.40K | $394.74K | 0.00% | New |
| Morgan Stanley history | 169.02K | $228.18K | 0.00% | Add |
| Goldman Sachs Group history | 59.35K | $80.12K | 0.00% | Reduce |
| Bank of America Corp history | 57.80K | $78.04K | 0.00% | Add |
| Prudential Financial history | 35.00K | $47.24K | 0.00% | New |
| JPMorgan Chase & Co history | 30.04K | $40.55K | 0.00% | Add |
| BNY Mellon history | 19.12K | $25.82K | 0.00% | Hold |
| Citigroup Inc history | 18.12K | $24.46K | 0.00% | Reduce |
| PNC Financial Services history | 1.46K | $1.97K | 0.00% | Hold |
| Wells Fargo & Co history | 301 | $406 | 0.00% | Reduce |
Q2 2025 — 22 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 38.14M | $36.07M | 0.00% | Add |
| Vanguard Group history | 8.85M | $8.37M | 0.00% | Reduce |
| BlackRock Inc history | 3.35M | $3.17M | 0.00% | Reduce |
| Geode Capital Management history | 2.38M | $2.25M | 0.00% | Reduce |
| Millennium Management history | 1.64M | $1.55M | 0.00% | Add |
| AQR Capital Management history | 1.40M | $1.33M | 0.00% | Add |
| Charles Schwab Investment Management history | 883.23K | $835.27K | 0.00% | Reduce |
| Wellington Management Group history | 486.67K | $460.25K | 0.00% | New |
| Invesco Ltd history | 420.70K | $397.86K | 0.00% | Add |
| Northern Trust Corp history | 416.37K | $393.76K | 0.00% | Reduce |
| Two Sigma Investments history | 403.92K | $381.99K | 0.00% | New |
| UBS Group AG history | 400.73K | $379.09K | 0.00% | Reduce |
| Goldman Sachs Group history | 325.75K | $308.06K | 0.00% | Reduce |
| Citadel Advisors history | 275.60K | $260.63K | 0.00% | Add |
| Morgan Stanley history | 131.39K | $124.26K | 0.00% | Reduce |
| Citigroup Inc history | 48.54K | $45.91K | 0.00% | Reduce |
| Bank of America Corp history | 32.10K | $30.33K | 0.00% | Reduce |
| Wells Fargo & Co history | 26.42K | $24.99K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 24.68K | $23.34K | 0.00% | Reduce |
| D. E. Shaw & Co history | 23.72K | $22.43K | 0.00% | New |
| BNY Mellon history | 19.12K | $18.09K | 0.00% | Reduce |
| PNC Financial Services history | 1.46K | $1.38K | 0.00% | Hold |
Q1 2025 — 22 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Fidelity Management & Research (FMR) history | 34.54M | $15.92M | 0.00% | Reduce |
| BlackRock Inc history | 10.01M | $4.61M | 0.00% | Reduce |
| Vanguard Group history | 9.56M | $4.41M | 0.00% | Reduce |
| Geode Capital Management history | 3.69M | $1.70M | 0.00% | Add |
| UBS Group AG history | 2.10M | $965.95K | 0.00% | Add |
| AQR Capital Management history | 1.17M | $540.62K | 0.00% | New |
| Charles Schwab Investment Management history | 1.15M | $530.27K | 0.00% | Reduce |
| Northern Trust Corp history | 1.11M | $511.44K | 0.00% | Reduce |
| Morgan Stanley history | 641.63K | $295.66K | 0.00% | Add |
| Goldman Sachs Group history | 355.15K | $163.65K | 0.00% | Reduce |
| BNY Mellon history | 310.12K | $142.90K | 0.00% | Reduce |
| Invesco Ltd history | 285.76K | $131.68K | 0.00% | Add |
| Citadel Advisors history | 201.11K | $92.67K | 0.00% | Reduce |
| Millennium Management history | 100.00K | $46.08K | 0.00% | New |
| Citigroup Inc history | 96.97K | $44.68K | 0.00% | Reduce |
| Bank of America Corp history | 96.39K | $44.34K | 0.00% | Reduce |
| Deutsche Bank AG history | 94.39K | $43.42K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 88.20K | $40.64K | 0.00% | Add |
| Wells Fargo & Co history | 63.93K | $29.46K | 0.00% | Add |
| Legal & General Investment Management America history | 11.47K | $5.28K | 0.00% | Reduce |
| PNC Financial Services history | 1.46K | $673 | 0.00% | Add |
| T. Rowe Price Associates history | 92.25K | $43 | 0.00% | Add |
New Positions (Q2 2026)
- CPP Investments 257.90K sh · $618.96K
- Deutsche Bank AG 247.53K sh · $594.07K
- Wellington Management Group 179.70K sh · $431.28K
- JPMorgan Chase & Co 109.84K sh · $289.98K
- Manulife Financial 69.75K sh · $167.39K
- Legal & General Investment Management America 24.18K sh · $58.04K
- D. E. Shaw & Co 22.20K sh · $53.28K
- Principal Global Investors 19.03K sh · $45.68K
- T. Rowe Price Associates 204.39K sh · $491
Fully Exited (vs previous quarter)
- Marshall Wace sold 2.38M sh · $3.71M
Fund Position History — shares by quarter (top 20 funds)
| Fund | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 | Q1 2022 | Q4 2021 | Q3 2021 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fidelity Management & Research (FMR) | 51.78M | 45.06M | 37.83M | 38.68M | 38.14M | 34.54M | 51.97M | 49.87M | 38.69M | 13.89M | 2.28M | 7.56M | 8.51M | 5.24M | 5.25M | 5.28M | 5.29M | 5.29M | 5.67M | 6.46M |
| BlackRock Inc | 17.35M | 3.32M | 3.19M | 3.39M | 3.35M | 10.01M | 10.33M | 10.13M | — | — | — | — | — | — | — | — | — | — | — | — |
| Point72 Asset Management | 8.25M | 7.81M | 284.02K | — | — | — | 8.99M | 1.23M | 4.12M | 584.39K | — | — | — | 516.37K | 1.34M | 3.61M | — | — | — | — |
| Geode Capital Management | 6.24M | 3.17M | 2.50M | 2.40M | 2.38M | 3.69M | 3.52M | 3.52M | 3.25M | 2.39M | 2.35M | 2.13M | 1.84M | 1.73M | 1.61M | 1.57M | 1.34M | 1.26M | 1.20M | 1.19M |
| Citadel Advisors | 1.99M | 1.69M | 2.27M | 3.09M | 275.60K | 201.11K | 216.83K | 240.82K | 2.55M | 370.38K | 903.06K | 97.21K | 547.92K | 176.83K | 192.98K | 149.69K | 232.98K | 471.81K | 99.85K | 120.56K |
| Northern Trust Corp | 1.97M | 494.67K | 412.16K | 369.79K | 416.37K | 1.11M | 1.31M | 1.14M | 997.53K | 866.56K | 859.59K | 1.15M | 1.08M | 763.26K | 786.97K | 735.51K | 672.46K | 660.41K | 688.38K | 688.08K |
| Charles Schwab Investment Management | 1.96M | 1.31M | 1.06M | 1.14M | 883.23K | 1.15M | 1.19M | 1.42M | 1.36M | 881.12K | 864.17K | 851.92K | 712.38K | 688.61K | 695.94K | 662.48K | 434.56K | 501.13K | 488.42K | 475.79K |
| Millennium Management | 1.13M | 4.94M | 4.82M | 3.83M | 1.64M | 100.00K | — | 1.40M | 597.32K | 534.18K | 1.63M | 3.89M | 2.63M | 23.84K | 1.18M | 905.91K | 217.95K | 368.65K | 255.14K | 78.04K |
| Renaissance Technologies | 1.13M | 1.60M | 263.25K | 292.40K | — | — | 51.14K | — | — | — | 412.18K | 272.25K | — | 263.88K | 393.29K | 481.38K | — | 88.78K | — | — |
| UBS Group AG | 684.71K | 2.48M | 3.01M | 352.92K | 400.73K | 2.10M | 686.12K | 139.99K | 161.11K | 166.96K | 169.62K | 125.36K | 97.56K | 138.73K | 159.82K | 93.69K | 212.15K | 212.07K | 96.00K | 3.97K |
| Two Sigma Investments | 643.44K | 1.20M | 637.31K | 559.01K | 403.92K | — | — | 204.88K | 19.16K | 189.43K | 202.89K | 645.37K | 127.64K | — | 115.23K | 43.30K | — | — | — | — |
| BNY Mellon | 568.71K | 27.46K | 19.12K | 19.12K | 19.12K | 310.12K | 314.92K | 314.78K | 401.91K | 292.01K | 341.08K | 331.32K | 337.68K | 317.50K | 326.02K | 291.66K | 257.10K | 284.61K | 284.25K | 260.99K |
| Invesco Ltd | 508.07K | 512.43K | 594.88K | 521.40K | 420.70K | 285.76K | 104.49K | 65.07K | 59.74K | 49.82K | 61.18K | 51.94K | 40.12K | 40.97K | 41.22K | 31.35K | 28.52K | 29.85K | 28.78K | 27.75K |
| Goldman Sachs Group | 485.55K | 1.07M | 921.20K | 59.35K | 325.75K | 355.15K | 540.21K | 401.29K | 373.43K | 156.21K | 235.34K | 359.71K | 553.01K | 288.94K | 266.36K | 240.92K | 208.03K | 182.67K | 157.48K | 89.91K |
| Bank of America Corp | 421.30K | 526.10K | 102.10K | 57.80K | 32.10K | 96.39K | 136.41K | 107.09K | 87.19K | 85.87K | 210.72K | 164.48K | 78.29K | 60.76K | 62.47K | 110.13K | 38.31K | 46.72K | 276.52K | 19.01K |
| CPP Investments | 257.90K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Deutsche Bank AG | 247.53K | — | — | — | — | 94.39K | 315.66K | 66.04K | 31.89K | 38.74K | 40.29K | 40.29K | 40.29K | 52.62K | 36.65K | 36.09K | 33.09K | 37.90K | 42.41K | 40.25K |
| Wells Fargo & Co | 230.47K | 7.76K | 1 | 301 | 26.42K | 63.93K | 62.52K | 76.49K | 45.60K | 31.02K | 26.73K | 21.16K | 36.83K | 15.36K | — | 761 | 1.33K | 179.95K | 492.73K | 552.96K |
| Wellington Management Group | 179.70K | — | — | — | 486.67K | — | 748.00K | 732.75K | 738.63K | 686.42K | — | 378.70K | 142.01K | 151.49K | 155.91K | 155.64K | 217.20K | 217.20K | 215.54K | — |
| Citigroup Inc | 175.21K | 166.40K | 91.67K | 18.12K | 48.54K | 96.97K | 106.79K | 89.75K | 33.13K | 17.55K | 225.00K | 36.02K | 33.49K | 4.04K | 4.22K | 4.64K | 16.55K | 8.68K | 23.61K | 8.94K |
▲ Bought Low (fund opened/added, stock rose ≥5% next quarter) ▼ Sold High (fund reduced, stock fell ≥5% next quarter)
Drag / scroll to zoom · Default shows the most recent year · Annotations come from quarterly fund actions in 13F filings · Hover a marker for details