KPTI — KARYOPHARM THERAPEUTICS INC
Reported value held$65.16M
Funds holding (latest)26
SectorHealth Care
Funds holding (Q2 2026)23
Institutional value$59.92M · 6.16M sh
New / Add / Cut / Exit4 / 15 / 2 / 2
Top-5 / Top-10 concentration72.1% / 90.6%
Institutional holdings change
Accumulating +69.6%
(+2.53M sh)
Institutional value change
Up +197.1%
As of Q2 2026, 23 SEC-registered investment managers reported holding KPTI (KARYOPHARM THERAPEUTICS INC) in their latest 13F filings, with a combined reported value of $59.92M across 6.16M shares. That is +69.6% by share count (+2.53M shares) versus the previous quarter, while reported value moved +197.1%. Ownership is concentrated: the five largest holders account for 72.1% of reported value and the top ten for 90.6%.
Compared with the prior quarter, 4 opened new positions, 15 added to existing stakes, 2 trimmed, 2 exited entirely. 13F holdings are quarter-end snapshots, so these moves reflect positioning as of Q2 2026, not real-time trading.
KPTI is classified in the Health Care sector.
All figures on this page are computed from SEC Form 13F quarterly filings. 13F filers disclose long positions of $100,000 or more within 45 days of quarter end; short positions, options overlays and intra-quarter trades are not included, so treat the numbers as a quarterly snapshot of institutional ownership rather than real-time positioning.
Q2 2026 — 23 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Goldman Sachs Group history | 1.42M | $13.92M | 0.00% | Add |
| BlackRock Inc history | 1.42M | $13.86M | 0.00% | Add |
| Two Sigma Investments history | 695.26K | $6.79M | 0.01% | Add |
| Geode Capital Management history | 531.23K | $5.19M | 0.00% | Add |
| UBS Group AG history | 353.55K | $3.45M | 0.00% | Add |
| Millennium Management history | 341.68K | $3.34M | 0.00% | Reduce |
| Davidson Kempner Capital Management history | 300.00K | $2.93M | 0.04% | Hold |
| Morgan Stanley history | 202.51K | $1.98M | 0.00% | Add |
| Northern Trust Corp history | 160.01K | $1.56M | 0.00% | Add |
| Marshall Wace history | 128.45K | $1.25M | 0.00% | Hold |
| Citadel Advisors history | 117.97K | $1.15M | 0.00% | Reduce |
| Renaissance Technologies history | 108.21K | $1.06M | 0.00% | Add |
| Invesco Ltd history | 90.30K | $882.27K | 0.00% | Add |
| Charles Schwab Investment Management history | 61.94K | $605.18K | 0.00% | Add |
| BNY Mellon history | 57.26K | $559.45K | 0.00% | Add |
| Bank of America Corp history | 49.92K | $487.76K | 0.00% | Add |
| Citigroup Inc history | 37.92K | $370.45K | 0.00% | Add |
| Deutsche Bank AG history | 19.43K | $189.78K | 0.00% | New |
| Wells Fargo & Co history | 16.90K | $165.14K | 0.00% | New |
| Fidelity Management & Research (FMR) history | 8.94K | $87.31K | 0.00% | Add |
| JPMorgan Chase & Co history | 6.30K | $63.54K | 0.00% | New |
| Legal & General Investment Management America history | 1.94K | $18.91K | 0.00% | New |
| T. Rowe Price Associates history | 27.23K | $266 | 0.00% | Add |
Q1 2026 — 21 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Goldman Sachs Group history | 947.58K | $5.28M | 0.00% | New |
| Millennium Management history | 511.57K | $2.85M | 0.00% | New |
| Citadel Advisors history | 507.50K | $2.83M | 0.00% | Add |
| Davidson Kempner Capital Management history | 300.00K | $1.67M | 0.03% | Reduce |
| BlackRock Inc history | 244.90K | $1.36M | 0.00% | Reduce |
| Geode Capital Management history | 206.13K | $1.15M | 0.00% | Add |
| UBS Group AG history | 194.02K | $1.08M | 0.00% | Add |
| Balyasny Asset Management history | 170.75K | $951.07K | 0.00% | New |
| Two Sigma Investments history | 151.23K | $842.36K | 0.00% | Add |
| Marshall Wace history | 128.45K | $715.47K | 0.00% | Hold |
| Renaissance Technologies history | 105.41K | $587.16K | 0.00% | Add |
| Northern Trust Corp history | 38.56K | $214.76K | 0.00% | Add |
| Point72 Asset Management history | 30.00K | $167.10K | 0.00% | New |
| Bank of America Corp history | 19.47K | $108.46K | 0.00% | Reduce |
| Morgan Stanley history | 18.57K | $103.44K | 0.00% | Add |
| Invesco Ltd history | 16.74K | $93.23K | 0.00% | New |
| Charles Schwab Investment Management history | 13.43K | $74.80K | 0.00% | New |
| BNY Mellon history | 11.40K | $63.49K | 0.00% | Add |
| Citigroup Inc history | 4.94K | $27.52K | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 665 | $3.70K | 0.00% | Reduce |
| T. Rowe Price Associates history | 10.89K | $61 | 0.00% | Hold |
Q4 2025 — 17 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 559.62K | $4.12M | 0.00% | Add |
| Davidson Kempner Capital Management history | 310.02K | $2.28M | 0.04% | Reduce |
| BlackRock Inc history | 247.56K | $1.82M | 0.00% | Add |
| Geode Capital Management history | 187.73K | $1.38M | 0.00% | Add |
| Two Sigma Investments history | 148.79K | $1.10M | 0.00% | New |
| Citadel Advisors history | 135.51K | $997.35K | 0.00% | Add |
| Marshall Wace history | 128.45K | $945.40K | 0.00% | Hold |
| UBS Group AG history | 88.45K | $651.03K | 0.00% | Add |
| Renaissance Technologies history | 59.91K | $440.97K | 0.00% | Reduce |
| Bank of America Corp history | 48.09K | $353.93K | 0.00% | Add |
| Northern Trust Corp history | 29.02K | $213.61K | 0.00% | Add |
| BNY Mellon history | 11.09K | $81.60K | 0.00% | Hold |
| Morgan Stanley history | 8.86K | $65.19K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 1.74K | $12.81K | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 679 | $5.00K | 0.00% | Hold |
| T. Rowe Price Associates history | 10.89K | $81 | 0.00% | Hold |
| Citigroup Inc history | 1 | $7 | 0.00% | Reduce |
Q3 2025 — 17 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Davidson Kempner Capital Management history | 30.00M | $20.88M | 0.42% | Hold |
| Vanguard Group history | 408.22K | $2.67M | 0.00% | Reduce |
| BlackRock Inc history | 231.95K | $1.52M | 0.00% | Reduce |
| Marshall Wace history | 128.45K | $840.07K | 0.00% | Hold |
| Geode Capital Management history | 93.29K | $610.25K | 0.00% | Add |
| Citadel Advisors history | 92.00K | $601.68K | 0.00% | Reduce |
| Renaissance Technologies history | 64.71K | $423.23K | 0.00% | Reduce |
| UBS Group AG history | 59.69K | $390.34K | 0.00% | Reduce |
| Morgan Stanley history | 25.77K | $168.51K | 0.00% | Add |
| Goldman Sachs Group history | 24.89K | $162.75K | 0.00% | Reduce |
| Northern Trust Corp history | 18.88K | $123.45K | 0.00% | Hold |
| BNY Mellon history | 11.09K | $72.50K | 0.00% | Hold |
| Fidelity Management & Research (FMR) history | 679 | $4.44K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 550 | $3.60K | 0.00% | Reduce |
| Citigroup Inc history | 513 | $3.35K | 0.00% | Reduce |
| Bank of America Corp history | 94 | $615 | 0.00% | Reduce |
| T. Rowe Price Associates history | 10.89K | $72 | 0.00% | Hold |
Q2 2025 — 18 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Davidson Kempner Capital Management history | 30.00M | $21.24M | 0.40% | New |
| Vanguard Group history | 518.27K | $2.23M | 0.00% | Add |
| BlackRock Inc history | 236.64K | $1.02M | 0.00% | Reduce |
| Citadel Advisors history | 223.00K | $961.15K | 0.00% | Add |
| Bank of America Corp history | 168.53K | $726.38K | 0.00% | Add |
| UBS Group AG history | 161.90K | $697.79K | 0.00% | Add |
| Marshall Wace history | 128.45K | $553.62K | 0.00% | Hold |
| Goldman Sachs Group history | 109.40K | $471.53K | 0.00% | Add |
| Geode Capital Management history | 91.84K | $395.92K | 0.00% | Reduce |
| Renaissance Technologies history | 65.81K | $283.66K | 0.00% | Add |
| Millennium Management history | 31.85K | $137.26K | 0.00% | Reduce |
| Morgan Stanley history | 25.09K | $108.14K | 0.00% | Add |
| Northern Trust Corp history | 18.91K | $81.50K | 0.00% | Hold |
| BNY Mellon history | 11.09K | $47.78K | 0.00% | Hold |
| Citigroup Inc history | 7.04K | $30.34K | 0.00% | Hold |
| JPMorgan Chase & Co history | 38.00K | $29.83K | 0.00% | Hold |
| Fidelity Management & Research (FMR) history | 765 | $3.30K | 0.00% | Add |
| T. Rowe Price Associates history | 10.89K | $47 | 0.00% | New |
Q1 2025 — 16 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 510.29K | $1.91M | 0.00% | New |
| BlackRock Inc history | 242.74K | $907.86K | 0.00% | New |
| Citadel Advisors history | 221.28K | $827.61K | 0.00% | New |
| Bank of America Corp history | 132.91K | $497.07K | 0.00% | New |
| Marshall Wace history | 128.45K | $480.41K | 0.00% | New |
| Geode Capital Management history | 99.64K | $372.74K | 0.00% | New |
| UBS Group AG history | 93.61K | $350.11K | 0.00% | New |
| Goldman Sachs Group history | 85.41K | $319.43K | 0.00% | New |
| Renaissance Technologies history | 61.21K | $228.94K | 0.00% | New |
| Millennium Management history | 55.37K | $207.07K | 0.00% | New |
| Northern Trust Corp history | 18.91K | $70.72K | 0.00% | New |
| BNY Mellon history | 11.09K | $41.46K | 0.00% | New |
| Morgan Stanley history | 10.42K | $38.98K | 0.00% | New |
| JPMorgan Chase & Co history | 38.00K | $29.83K | 0.00% | Hold |
| Citigroup Inc history | 7.04K | $26.34K | 0.00% | New |
| Fidelity Management & Research (FMR) history | 527 | $1.97K | 0.00% | New |
New Positions (Q2 2026)
- Deutsche Bank AG 19.43K sh · $189.78K
- Wells Fargo & Co 16.90K sh · $165.14K
- JPMorgan Chase & Co 6.30K sh · $63.54K
- Legal & General Investment Management America 1.94K sh · $18.91K
Fully Exited (vs previous quarter)
- Balyasny Asset Management sold 170.75K sh · $951.07K
- Point72 Asset Management sold 30.00K sh · $167.10K
Fund Position History — shares by quarter (top 20 funds)
| Fund | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 | Q1 2022 | Q4 2021 | Q3 2021 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Goldman Sachs Group | 1.42M | 947.58K | — | 24.89K | 109.40K | 85.41K | — | — | — | — | — | — | — | — | — | — | — | 200.00K | 200.00K | 100.00K |
| BlackRock Inc | 1.42M | 244.90K | 247.56K | 231.95K | 236.64K | 242.74K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Two Sigma Investments | 695.26K | 151.23K | 148.79K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Geode Capital Management | 531.23K | 206.13K | 187.73K | 93.29K | 91.84K | 99.64K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| UBS Group AG | 353.55K | 194.02K | 88.45K | 59.69K | 161.90K | 93.61K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Millennium Management | 341.68K | 511.57K | — | — | 31.85K | 55.37K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Davidson Kempner Capital Management | 300.00K | 300.00K | 310.02K | 30.00M | 30.00M | — | — | — | — | 29.00M | 25.00M | 25.00M | 25.00M | 25.00M | 25.00M | 25.00M | 25.00M | 25.00M | 25.00M | 23.00M |
| Morgan Stanley | 202.51K | 18.57K | 8.86K | 25.77K | 25.09K | 10.42K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Northern Trust Corp | 160.01K | 38.56K | 29.02K | 18.88K | 18.91K | 18.91K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Marshall Wace | 128.45K | 128.45K | 128.45K | 128.45K | 128.45K | 128.45K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Citadel Advisors | 117.97K | 507.50K | 135.51K | 92.00K | 223.00K | 221.28K | — | — | — | — | — | — | — | — | — | — | — | — | 29.80M | 53.30M |
| Renaissance Technologies | 108.21K | 105.41K | 59.91K | 64.71K | 65.81K | 61.21K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Invesco Ltd | 90.30K | 16.74K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Charles Schwab Investment Management | 61.94K | 13.43K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| BNY Mellon | 57.26K | 11.40K | 11.09K | 11.09K | 11.09K | 11.09K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Bank of America Corp | 49.92K | 19.47K | 48.09K | 94 | 168.53K | 132.91K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Citigroup Inc | 37.92K | 4.94K | 1 | 513 | 7.04K | 7.04K | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Deutsche Bank AG | 19.43K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Wells Fargo & Co | 16.90K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Fidelity Management & Research (FMR) | 8.94K | 665 | 679 | 679 | 765 | 527 | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
▲ Bought Low (fund opened/added, stock rose ≥5% next quarter) ▼ Sold High (fund reduced, stock fell ≥5% next quarter)
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