DSGN — DESIGN THERAPEUTICS INC
Reported value held$178.93M
Funds holding (latest)35
SectorHealth Care
Funds holding (Q2 2026)29
Institutional value$150.70M · 10.44M sh
New / Add / Cut / Exit3 / 18 / 7 / 1
Top-5 / Top-10 concentration72.3% / 90.5%
Institutional holdings change
Accumulating +5.6%
(+555.15K sh)
Institutional value change
Up +43.5%
As of Q2 2026, 29 SEC-registered investment managers reported holding DSGN (DESIGN THERAPEUTICS INC) in their latest 13F filings, with a combined reported value of $150.70M across 10.44M shares. That is +5.6% by share count (+555.15K shares) versus the previous quarter, while reported value moved +43.5%. Ownership is concentrated: the five largest holders account for 72.3% of reported value and the top ten for 90.5%.
Compared with the prior quarter, 3 opened new positions, 18 added to existing stakes, 7 trimmed, 1 exited entirely. 13F holdings are quarter-end snapshots, so these moves reflect positioning as of Q2 2026, not real-time trading.
DSGN is classified in the Health Care sector.
All figures on this page are computed from SEC Form 13F quarterly filings. 13F filers disclose long positions of $100,000 or more within 45 days of quarter end; short positions, options overlays and intra-quarter trades are not included, so treat the numbers as a quarterly snapshot of institutional ownership rather than real-time positioning.
Q2 2026 — 29 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| BlackRock Inc history | 2.66M | $38.49M | 0.00% | Add |
| Point72 Asset Management history | 2.37M | $34.24M | 0.04% | Reduce |
| Geode Capital Management history | 958.42K | $13.87M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 776.46K | $11.24M | 0.00% | Reduce |
| Morgan Stanley history | 765.42K | $11.08M | 0.00% | Add |
| Goldman Sachs Group history | 656.58K | $9.50M | 0.00% | Add |
| Renaissance Technologies history | 387.91K | $5.61M | 0.01% | Reduce |
| Northern Trust Corp history | 353.20K | $5.11M | 0.00% | Add |
| Charles Schwab Investment Management history | 271.26K | $3.93M | 0.00% | Add |
| Prudential Financial history | 224.17K | $3.24M | 0.00% | Add |
| D. E. Shaw & Co history | 195.65K | $2.83M | 0.00% | Reduce |
| Millennium Management history | 147.71K | $2.14M | 0.00% | Add |
| Balyasny Asset Management history | 111.10K | $1.61M | 0.00% | New |
| Citadel Advisors history | 95.87K | $1.39M | 0.00% | Reduce |
| BNY Mellon history | 92.07K | $1.33M | 0.00% | Add |
| AQR Capital Management history | 71.11K | $1.03M | 0.00% | Add |
| Bank of America Corp history | 43.73K | $632.75K | 0.00% | Add |
| UBS Group AG history | 34.76K | $502.99K | 0.00% | Add |
| Two Sigma Investments history | 32.92K | $476.43K | 0.00% | Add |
| CPP Investments history | 32.60K | $471.72K | 0.00% | Reduce |
| Deutsche Bank AG history | 30.61K | $442.97K | 0.00% | Add |
| Wells Fargo & Co history | 28.07K | $406.20K | 0.00% | Add |
| Invesco Ltd history | 21.43K | $310.08K | 0.00% | Reduce |
| Wellington Management Group history | 19.40K | $280.72K | 0.00% | New |
| JPMorgan Chase & Co history | 16.90K | $240.71K | 0.00% | New |
| Citigroup Inc history | 15.88K | $229.78K | 0.00% | Add |
| Legal & General Investment Management America history | 2.99K | $43.22K | 0.00% | Add |
| PNC Financial Services history | 1.82K | $26.28K | 0.00% | Hold |
| T. Rowe Price Associates history | 25.61K | $371 | 0.00% | Add |
Q1 2026 — 27 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Point72 Asset Management history | 2.72M | $28.97M | 0.04% | Reduce |
| BlackRock Inc history | 2.13M | $22.70M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 798.41K | $8.50M | 0.00% | Add |
| Geode Capital Management history | 692.52K | $7.37M | 0.00% | Add |
| Morgan Stanley history | 656.57K | $6.99M | 0.00% | Reduce |
| Goldman Sachs Group history | 504.72K | $5.37M | 0.00% | Add |
| D. E. Shaw & Co history | 470.27K | $5.00M | 0.00% | Add |
| Renaissance Technologies history | 408.20K | $4.34M | 0.01% | Add |
| Northern Trust Corp history | 300.28K | $3.19M | 0.00% | Add |
| Charles Schwab Investment Management history | 241.49K | $2.57M | 0.00% | Add |
| Citadel Advisors history | 231.51K | $2.46M | 0.00% | Reduce |
| Marshall Wace history | 151.01K | $1.61M | 0.00% | Reduce |
| Invesco Ltd history | 141.92K | $1.51M | 0.00% | Reduce |
| Millennium Management history | 108.93K | $1.16M | 0.00% | Reduce |
| BNY Mellon history | 79.64K | $847.42K | 0.00% | Reduce |
| CPP Investments history | 60.40K | $642.66K | 0.00% | Add |
| Prudential Financial history | 45.81K | $487.42K | 0.00% | Add |
| AQR Capital Management history | 25.96K | $276.18K | 0.00% | Add |
| Bank of America Corp history | 23.26K | $247.53K | 0.00% | Reduce |
| Deutsche Bank AG history | 20.64K | $219.65K | 0.00% | Add |
| UBS Group AG history | 17.09K | $181.85K | 0.00% | Reduce |
| Two Sigma Investments history | 16.30K | $173.43K | 0.00% | Reduce |
| Wells Fargo & Co history | 9.03K | $96.05K | 0.00% | Reduce |
| Citigroup Inc history | 4.26K | $45.36K | 0.00% | Add |
| Legal & General Investment Management America history | 2.08K | $22.10K | 0.00% | Hold |
| PNC Financial Services history | 1.82K | $19.32K | 0.00% | Hold |
| T. Rowe Price Associates history | 16.37K | $175 | 0.00% | Add |
Q4 2025 — 29 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Point72 Asset Management history | 5.37M | $50.39M | 0.06% | Add |
| BlackRock Inc history | 2.12M | $19.86M | 0.00% | Add |
| Vanguard Group history | 1.63M | $15.30M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 771.27K | $7.23M | 0.00% | Add |
| Morgan Stanley history | 702.31K | $6.59M | 0.00% | Add |
| Geode Capital Management history | 679.59K | $6.38M | 0.00% | Reduce |
| Citadel Advisors history | 459.87K | $4.31M | 0.00% | Reduce |
| D. E. Shaw & Co history | 438.89K | $4.12M | 0.00% | Add |
| Invesco Ltd history | 305.76K | $2.87M | 0.00% | Add |
| Renaissance Technologies history | 287.10K | $2.69M | 0.00% | Add |
| Northern Trust Corp history | 286.57K | $2.69M | 0.00% | Reduce |
| Goldman Sachs Group history | 270.65K | $2.54M | 0.00% | Add |
| Charles Schwab Investment Management history | 236.86K | $2.22M | 0.00% | Reduce |
| Marshall Wace history | 225.53K | $2.12M | 0.00% | New |
| Millennium Management history | 180.87K | $1.70M | 0.00% | Add |
| BNY Mellon history | 84.97K | $797.07K | 0.00% | Reduce |
| CPP Investments history | 54.60K | $512.15K | 0.00% | New |
| Two Sigma Investments history | 46.24K | $433.70K | 0.00% | Reduce |
| Prudential Financial history | 42.71K | $400.62K | 0.00% | Reduce |
| Bank of America Corp history | 27.45K | $257.44K | 0.00% | Add |
| Wells Fargo & Co history | 26.79K | $251.25K | 0.00% | Add |
| UBS Group AG history | 25.54K | $239.54K | 0.00% | Add |
| Deutsche Bank AG history | 15.54K | $145.78K | 0.00% | New |
| JPMorgan Chase & Co history | 14.45K | $135.55K | 0.00% | Reduce |
| AQR Capital Management history | 13.73K | $128.79K | 0.00% | Hold |
| Citigroup Inc history | 3.11K | $29.20K | 0.00% | Add |
| Legal & General Investment Management America history | 2.08K | $19.48K | 0.00% | Hold |
| PNC Financial Services history | 1.82K | $17.04K | 0.00% | Hold |
| T. Rowe Price Associates history | 15.71K | $148 | 0.00% | Reduce |
Q3 2025 — 26 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Point72 Asset Management history | 3.34M | $25.15M | 0.04% | Add |
| BlackRock Inc history | 2.04M | $15.39M | 0.00% | Reduce |
| Vanguard Group history | 1.44M | $10.87M | 0.00% | Reduce |
| Fidelity Management & Research (FMR) history | 740.85K | $5.58M | 0.00% | Reduce |
| Geode Capital Management history | 695.61K | $5.24M | 0.00% | Reduce |
| Citadel Advisors history | 554.02K | $4.17M | 0.00% | Reduce |
| D. E. Shaw & Co history | 373.28K | $2.81M | 0.00% | Reduce |
| Northern Trust Corp history | 296.53K | $2.23M | 0.00% | Reduce |
| Renaissance Technologies history | 274.30K | $2.07M | 0.00% | Add |
| Goldman Sachs Group history | 261.44K | $1.97M | 0.00% | Add |
| Charles Schwab Investment Management history | 247.93K | $1.87M | 0.00% | Reduce |
| Morgan Stanley history | 175.99K | $1.33M | 0.00% | Reduce |
| BNY Mellon history | 87.47K | $658.69K | 0.00% | Reduce |
| Millennium Management history | 68.82K | $518.24K | 0.00% | New |
| Two Sigma Investments history | 59.24K | $446.06K | 0.00% | Reduce |
| Prudential Financial history | 44.83K | $337.53K | 0.00% | Reduce |
| Bank of America Corp history | 23.91K | $180.02K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 23.22K | $174.85K | 0.00% | Add |
| UBS Group AG history | 22.69K | $170.88K | 0.00% | Reduce |
| Wells Fargo & Co history | 18.32K | $137.93K | 0.00% | Reduce |
| Invesco Ltd history | 14.59K | $109.85K | 0.00% | Add |
| AQR Capital Management history | 13.66K | $102.89K | 0.00% | Reduce |
| Legal & General Investment Management America history | 2.08K | $15.66K | 0.00% | Reduce |
| PNC Financial Services history | 1.82K | $13.73K | 0.00% | Add |
| Citigroup Inc history | 1.59K | $11.97K | 0.00% | Reduce |
| T. Rowe Price Associates history | 16.31K | $123 | 0.00% | Hold |
Q2 2025 — 27 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| BlackRock Inc history | 2.40M | $8.07M | 0.00% | Reduce |
| Point72 Asset Management history | 1.81M | $6.09M | 0.01% | Reduce |
| Vanguard Group history | 1.47M | $4.96M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 951.20K | $3.21M | 0.00% | Hold |
| Citadel Advisors history | 840.79K | $2.83M | 0.00% | Reduce |
| Geode Capital Management history | 794.01K | $2.68M | 0.00% | Add |
| D. E. Shaw & Co history | 390.65K | $1.32M | 0.00% | Reduce |
| Northern Trust Corp history | 362.52K | $1.22M | 0.00% | Reduce |
| Renaissance Technologies history | 267.80K | $902.49K | 0.00% | Add |
| Charles Schwab Investment Management history | 250.95K | $845.70K | 0.00% | Reduce |
| Goldman Sachs Group history | 239.46K | $806.98K | 0.00% | Reduce |
| Morgan Stanley history | 213.55K | $719.66K | 0.00% | Reduce |
| BNY Mellon history | 94.60K | $318.81K | 0.00% | Reduce |
| Two Sigma Investments history | 89.31K | $300.98K | 0.00% | Reduce |
| Prudential Financial history | 57.92K | $195.21K | 0.00% | Add |
| AQR Capital Management history | 28.73K | $96.81K | 0.00% | Reduce |
| Deutsche Bank AG history | 28.09K | $94.68K | 0.00% | Hold |
| UBS Group AG history | 27.34K | $92.14K | 0.00% | Reduce |
| Bank of America Corp history | 24.62K | $82.98K | 0.00% | Add |
| Wells Fargo & Co history | 20.28K | $68.36K | 0.00% | Add |
| JPMorgan Chase & Co history | 18.32K | $61.76K | 0.00% | Reduce |
| Invesco Ltd history | 14.36K | $48.41K | 0.00% | Add |
| Citigroup Inc history | 13.65K | $45.99K | 0.00% | Reduce |
| Manulife Financial history | 11.96K | $40.29K | 0.00% | Reduce |
| Legal & General Investment Management America history | 3.08K | $10.39K | 0.00% | Add |
| PNC Financial Services history | 1.67K | $5.63K | 0.00% | Reduce |
| T. Rowe Price Associates history | 16.31K | $55 | 0.00% | Add |
Q1 2025 — 29 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| BlackRock Inc history | 2.48M | $9.57M | 0.00% | Reduce |
| Point72 Asset Management history | 1.82M | $7.02M | 0.02% | Reduce |
| Vanguard Group history | 1.43M | $5.51M | 0.00% | Hold |
| Citadel Advisors history | 970.56K | $3.75M | 0.00% | Hold |
| Fidelity Management & Research (FMR) history | 948.05K | $3.66M | 0.00% | Hold |
| Geode Capital Management history | 775.50K | $2.99M | 0.00% | Add |
| D. E. Shaw & Co history | 395.25K | $1.53M | 0.00% | Reduce |
| Northern Trust Corp history | 373.65K | $1.44M | 0.00% | Reduce |
| Goldman Sachs Group history | 266.02K | $1.03M | 0.00% | Reduce |
| Renaissance Technologies history | 265.00K | $1.02M | 0.00% | Add |
| Charles Schwab Investment Management history | 258.38K | $997.33K | 0.00% | Reduce |
| Morgan Stanley history | 247.88K | $956.81K | 0.00% | Reduce |
| Wellington Management Group history | 141.52K | $546.26K | 0.00% | New |
| Two Sigma Investments history | 128.75K | $496.96K | 0.00% | Reduce |
| BNY Mellon history | 95.35K | $368.04K | 0.00% | Hold |
| Millennium Management history | 87.99K | $339.63K | 0.00% | New |
| Prudential Financial history | 56.41K | $217.72K | 0.00% | Hold |
| UBS Group AG history | 32.82K | $126.68K | 0.00% | Reduce |
| AQR Capital Management history | 31.74K | $122.52K | 0.00% | Add |
| Deutsche Bank AG history | 28.13K | $108.58K | 0.00% | Hold |
| Citigroup Inc history | 22.88K | $88.31K | 0.00% | Reduce |
| Bank of America Corp history | 22.17K | $85.56K | 0.00% | Reduce |
| JPMorgan Chase & Co history | 19.28K | $74.41K | 0.00% | Reduce |
| Wells Fargo & Co history | 18.85K | $72.75K | 0.00% | Add |
| Manulife Financial history | 12.96K | $50.01K | 0.00% | Reduce |
| Invesco Ltd history | 11.33K | $43.74K | 0.00% | Reduce |
| PNC Financial Services history | 9.25K | $35.71K | 0.00% | Hold |
| Legal & General Investment Management America history | 2.56K | $9.91K | 0.00% | Hold |
| T. Rowe Price Associates history | 13.07K | $51 | 0.00% | Add |
New Positions (Q2 2026)
- Balyasny Asset Management 111.10K sh · $1.61M
- Wellington Management Group 19.40K sh · $280.72K
- JPMorgan Chase & Co 16.90K sh · $240.71K
Fully Exited (vs previous quarter)
- Marshall Wace sold 151.01K sh · $1.61M
Fund Position History — shares by quarter (top 20 funds)
| Fund | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 | Q1 2022 | Q4 2021 | Q3 2021 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BlackRock Inc | 2.66M | 2.13M | 2.12M | 2.04M | 2.40M | 2.48M | 2.58M | 2.36M | — | — | — | — | — | — | — | — | — | — | — | — |
| Point72 Asset Management | 2.37M | 2.72M | 5.37M | 3.34M | 1.81M | 1.82M | 1.86M | 1.60M | 990.80K | 593.52K | — | 1 | 5.35K | 10.13K | — | — | — | — | — | — |
| Geode Capital Management | 958.42K | 692.52K | 679.59K | 695.61K | 794.01K | 775.50K | 761.64K | 758.55K | 707.97K | 683.90K | 662.74K | 634.72K | 636.85K | 633.01K | 603.01K | 576.71K | 435.12K | 366.75K | 351.44K | 258.03K |
| Fidelity Management & Research (FMR) | 776.46K | 798.41K | 771.27K | 740.85K | 951.20K | 948.05K | 951.88K | 828.66K | 81.02K | 78.34K | 79.01K | 70.06K | 637.77K | 957.90K | 1.12M | 1.08M | 1.03M | 1.03M | 1.00M | 1.00M |
| Morgan Stanley | 765.42K | 656.57K | 702.31K | 175.99K | 213.55K | 247.88K | 346.18K | 428.80K | 389.44K | 478.09K | 543.48K | 360.26K | 190.77K | 69.38K | 41.42K | 58.94K | 38.83K | 12.82K | 13.30K | 7.40K |
| Goldman Sachs Group | 656.58K | 504.72K | 270.65K | 261.44K | 239.46K | 266.02K | 297.13K | 275.53K | 603.71K | 506.26K | 1.02M | 444.50K | 447.42K | 300.62K | 274.47K | 993.64K | 91.24K | 117.13K | 67.84K | 55.13K |
| Renaissance Technologies | 387.91K | 408.20K | 287.10K | 274.30K | 267.80K | 265.00K | 253.50K | 274.00K | 384.07K | 453.40K | 648.80K | 164.20K | 95.11K | 101.75K | — | — | — | — | — | — |
| Northern Trust Corp | 353.20K | 300.28K | 286.57K | 296.53K | 362.52K | 373.65K | 388.12K | 336.77K | 337.35K | 357.28K | 372.93K | 323.26K | 324.74K | 275.77K | 279.13K | 283.69K | 258.02K | 211.03K | 212.01K | 122.83K |
| Charles Schwab Investment Management | 271.26K | 241.49K | 236.86K | 247.93K | 250.95K | 258.38K | 264.68K | 257.43K | 179.96K | 179.17K | 175.65K | 173.54K | 228.81K | 230.35K | 230.91K | 224.56K | 134.78K | 122.37K | 118.56K | 90.52K |
| Prudential Financial | 224.17K | 45.81K | 42.71K | 44.83K | 57.92K | 56.41K | 56.31K | 59.12K | 63.22K | 46.81K | 18.41K | 18.41K | 26.21K | — | — | — | — | — | — | — |
| D. E. Shaw & Co | 195.65K | 470.27K | 438.89K | 373.28K | 390.65K | 395.25K | 512.33K | 582.86K | 535.78K | 446.19K | 290.63K | 11.74K | 135.28K | 111.30K | — | — | — | — | — | — |
| Millennium Management | 147.71K | 108.93K | 180.87K | 68.82K | — | 87.99K | — | 207.26K | 610.80K | 484.47K | 420.06K | 829.48K | 279.88K | 824.91K | 587.11K | 181.50K | — | — | — | 14.17K |
| Balyasny Asset Management | 111.10K | — | — | — | — | — | — | — | — | — | — | — | 18.50K | — | — | 11.13K | — | — | — | — |
| Citadel Advisors | 95.87K | 231.51K | 459.87K | 554.02K | 840.79K | 970.56K | 965.99K | 580.55K | 312.73K | 874.98K | 1.84M | 2.71M | 2.86M | 2.88M | 2.68M | 2.58M | 2.68M | 2.53M | 2.53M | 2.57M |
| BNY Mellon | 92.07K | 79.64K | 84.97K | 87.47K | 94.60K | 95.35K | 95.35K | 99.12K | 118.11K | 115.24K | 120.79K | 120.79K | 122.67K | 124.05K | 126.48K | 125.21K | 102.38K | 89.96K | 67.11K | 36.48K |
| AQR Capital Management | 71.11K | 25.96K | 13.73K | 13.66K | 28.73K | 31.74K | 29.86K | 10.78K | 11.08K | 11.75K | 56.24K | — | — | — | — | — | — | — | — | — |
| Bank of America Corp | 43.73K | 23.26K | 27.45K | 23.91K | 24.62K | 22.17K | 35.16K | 36.81K | 32.28K | 45.40K | 86.34K | 48.73K | 77.88K | 56.24K | 295.86K | 66.89K | 27.98K | 57.20K | 54.94K | 31.63K |
| UBS Group AG | 34.76K | 17.09K | 25.54K | 22.69K | 27.34K | 32.82K | 66.59K | 14.88K | 13.36K | 33.03K | 50.44K | 18.06K | 24.16K | 206 | 156.03K | — | — | 998 | 35 | 1.13K |
| Two Sigma Investments | 32.92K | 16.30K | 46.24K | 59.24K | 89.31K | 128.75K | 203.93K | 304.24K | 402.71K | 422.04K | 428.17K | 63.84K | 115.78K | 179.10K | 35.09K | — | — | — | — | — |
| CPP Investments | 32.60K | 60.40K | 54.60K | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
▲ Bought Low (fund opened/added, stock rose ≥5% next quarter) ▼ Sold High (fund reduced, stock fell ≥5% next quarter)
Drag / scroll to zoom · Default shows the most recent year · Annotations come from quarterly fund actions in 13F filings · Hover a marker for details