ALPN — ALPINE IMMUNE SCIENCES INC
Reported value held$420.18M
Funds holding (latest)35
Sector—
ALPN (ALPINE IMMUNE SCIENCES INC) is tracked on HoldingsHub across five years of quarterly 13F filings. 35 funds have reported positions historically, with the sum of their latest reported stakes valued at $420.18M. No fund in our coverage reported a position in the latest filing period, which typically means the stock has fallen out of the tracked funds' portfolios rather than that it cannot be bought.
All figures on this page are computed from SEC Form 13F quarterly filings. 13F filers disclose long positions of $100,000 or more within 45 days of quarter end; short positions, options overlays and intra-quarter trades are not included, so treat the numbers as a quarterly snapshot of institutional ownership rather than real-time positioning.
Q1 2024 — 33 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 2.71M | $107.51M | 0.00% | Add |
| Franklin Resources history | 1.09M | $43.33M | 0.01% | Reduce |
| Geode Capital Management history | 910.60K | $36.10M | 0.00% | Add |
| Morgan Stanley history | 789.64K | $31.30M | 0.00% | Add |
| Two Sigma Investments history | 519.97K | $20.61M | 0.05% | Add |
| Janus Henderson Group history | 450.83K | $17.84M | 0.01% | Reduce |
| D. E. Shaw & Co history | 428.56K | $16.99M | 0.02% | Add |
| Balyasny Asset Management history | 373.00K | $14.79M | 0.03% | New |
| Northern Trust Corp history | 341.70K | $13.55M | 0.00% | Add |
| Charles Schwab Investment Management history | 339.14K | $13.44M | 0.00% | Add |
| BNY Mellon history | 325.94K | $12.92M | 0.00% | Add |
| Invesco Ltd history | 272.63K | $10.81M | 0.00% | Add |
| Goldman Sachs Group history | 240.44K | $9.53M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 238.56K | $9.46M | 0.00% | Hold |
| Citadel Advisors history | 215.48K | $8.54M | 0.00% | Reduce |
| Citigroup Inc history | 207.50K | $8.23M | 0.01% | Add |
| Deutsche Bank AG history | 204.48K | $8.11M | 0.00% | Add |
| Bank of America Corp history | 202.41K | $8.02M | 0.00% | Add |
| Wellington Management Group history | 161.15K | $6.39M | 0.00% | Add |
| UBS Group AG history | 153.47K | $6.08M | 0.00% | Add |
| Point72 Asset Management history | 110.70K | $4.39M | 0.01% | New |
| Manulife Financial history | 83.87K | $3.32M | 0.00% | Add |
| Legal & General Investment Management America history | 30.90K | $1.22M | 0.00% | Add |
| JPMorgan Chase & Co history | 29.46K | $1.17M | 0.00% | Reduce |
| AQR Capital Management history | 18.08K | $716.65K | 0.00% | Reduce |
| Millennium Management history | 14.44K | $572.32K | 0.00% | Reduce |
| Wells Fargo & Co history | 12.53K | $496.53K | 0.00% | Add |
| Farallon Capital Management history | 5.90K | $233.88K | 0.00% | New |
| T. Rowe Price Associates history | 3.08M | $122.10K | 0.01% | Add |
| Renaissance Technologies history | 244.98K | $9.71K | 0.01% | Add |
| PNC Financial Services history | 54 | $2.14K | 0.00% | New |
| Arrowstreet Capital history | 18.98K | $752 | 0.00% | New |
| Lazard Asset Management history | 7.52K | $298 | 0.00% | Add |
Q4 2023 — 29 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 2.23M | $42.59M | 0.00% | Add |
| Franklin Resources history | 1.22M | $23.26M | 0.01% | New |
| Citadel Advisors history | 882.86K | $16.83M | 0.00% | Add |
| Geode Capital Management history | 764.35K | $14.57M | 0.00% | Add |
| Morgan Stanley history | 718.74K | $13.70M | 0.00% | Add |
| Janus Henderson Group history | 583.24K | $11.12M | 0.01% | New |
| Two Sigma Investments history | 378.41K | $7.21M | 0.02% | Add |
| Charles Schwab Investment Management history | 297.45K | $5.67M | 0.00% | Add |
| Northern Trust Corp history | 296.69K | $5.66M | 0.00% | Add |
| D. E. Shaw & Co history | 295.54K | $5.63M | 0.01% | Add |
| Millennium Management history | 273.07K | $5.20M | 0.00% | Add |
| Invesco Ltd history | 241.78K | $4.61M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 238.55K | $4.55M | 0.00% | Reduce |
| Marshall Wace history | 221.12K | $4.21M | 0.01% | New |
| Goldman Sachs Group history | 197.94K | $3.77M | 0.00% | Add |
| Deutsche Bank AG history | 129.48K | $2.47M | 0.00% | Add |
| Wellington Management Group history | 109.88K | $2.09M | 0.00% | Add |
| BNY Mellon history | 102.35K | $1.95M | 0.00% | Add |
| Bank of America Corp history | 91.77K | $1.75M | 0.00% | Add |
| UBS Group AG history | 65.81K | $1.25M | 0.00% | Add |
| Citigroup Inc history | 35.78K | $681.91K | 0.00% | Add |
| JPMorgan Chase & Co history | 33.07K | $630.39K | 0.00% | Add |
| AQR Capital Management history | 26.97K | $514.05K | 0.00% | New |
| Manulife Financial history | 26.78K | $510.39K | 0.00% | Reduce |
| Legal & General Investment Management America history | 26.26K | $500.57K | 0.00% | Add |
| Wells Fargo & Co history | 9.24K | $176.04K | 0.00% | Add |
| T. Rowe Price Associates history | 1.69M | $32.16K | 0.00% | Add |
| Renaissance Technologies history | 216.69K | $4.13K | 0.01% | Reduce |
| Lazard Asset Management history | 5.41K | $103 | 0.00% | New |
Q3 2023 — 25 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 1.47M | $16.89M | 0.00% | Add |
| Geode Capital Management history | 628.92K | $7.20M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 464.81K | $5.32M | 0.00% | Reduce |
| Northern Trust Corp history | 270.42K | $3.10M | 0.00% | Add |
| Charles Schwab Investment Management history | 234.26K | $2.68M | 0.00% | Add |
| Invesco Ltd history | 217.14K | $2.49M | 0.00% | New |
| Two Sigma Investments history | 190.59K | $2.18M | 0.01% | Add |
| BNY Mellon history | 92.72K | $1.06M | 0.00% | Add |
| Millennium Management history | 82.93K | $949.50K | 0.00% | Reduce |
| Goldman Sachs Group history | 66.44K | $760.80K | 0.00% | Add |
| Morgan Stanley history | 53.47K | $612.26K | 0.00% | Add |
| D. E. Shaw & Co history | 48.63K | $556.83K | 0.00% | New |
| Wellington Management Group history | 39.73K | $454.92K | 0.00% | New |
| JPMorgan Chase & Co history | 31.31K | $358.49K | 0.00% | Add |
| Citadel Advisors history | 29.87K | $342.06K | 0.00% | Reduce |
| Manulife Financial history | 28.38K | $324.99K | 0.00% | Add |
| Legal & General Investment Management America history | 22.71K | $260.09K | 0.00% | Add |
| Bank of America Corp history | 21.30K | $243.88K | 0.00% | Add |
| UBS Group AG history | 19.05K | $218.09K | 0.00% | Reduce |
| Deutsche Bank AG history | 17.51K | $200.50K | 0.00% | Reduce |
| Moore Capital Management history | 13.74K | $157.37K | 0.00% | Reduce |
| Wells Fargo & Co history | 7.04K | $80.55K | 0.00% | Reduce |
| T. Rowe Price Associates history | 1.40M | $15.99K | 0.00% | Add |
| Citigroup Inc history | 670 | $7.67K | 0.00% | Reduce |
| Renaissance Technologies history | 288.19K | $3.30K | 0.01% | Reduce |
Q2 2023 — 22 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 1.40M | $14.43M | 0.00% | Add |
| Fidelity Management & Research (FMR) history | 675.59K | $6.95M | 0.00% | Add |
| Geode Capital Management history | 617.97K | $6.35M | 0.00% | Add |
| Northern Trust Corp history | 257.52K | $2.65M | 0.00% | Add |
| Deutsche Bank AG history | 127.33K | $1.31M | 0.00% | Add |
| Millennium Management history | 116.17K | $1.19M | 0.00% | New |
| BNY Mellon history | 91.51K | $940.69K | 0.00% | Add |
| Charles Schwab Investment Management history | 86.28K | $886.96K | 0.00% | Add |
| Two Sigma Investments history | 58.03K | $596.53K | 0.00% | New |
| Citadel Advisors history | 56.02K | $575.92K | 0.00% | New |
| Goldman Sachs Group history | 55.77K | $573.37K | 0.00% | Add |
| Morgan Stanley history | 50.20K | $516.10K | 0.00% | Add |
| UBS Group AG history | 45.85K | $471.34K | 0.00% | Add |
| JPMorgan Chase & Co history | 26.35K | $270.87K | 0.00% | Reduce |
| Bank of America Corp history | 17.91K | $184.16K | 0.00% | Reduce |
| Moore Capital Management history | 13.84K | $142.32K | 0.00% | New |
| Manulife Financial history | 13.48K | $138.60K | 0.00% | New |
| Wells Fargo & Co history | 12.68K | $130.36K | 0.00% | Add |
| Citigroup Inc history | 10.28K | $105.64K | 0.00% | Add |
| Legal & General Investment Management America history | 3.49K | $35.90K | 0.00% | Add |
| Renaissance Technologies history | 319.29K | $3.28K | 0.01% | Reduce |
| T. Rowe Price Associates history | 21.74K | $224 | 0.00% | Add |
Q1 2023 — 17 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 1.37M | $10.57M | 0.00% | Add |
| Geode Capital Management history | 556.21K | $4.29M | 0.00% | Add |
| Northern Trust Corp history | 193.99K | $1.50M | 0.00% | Add |
| BNY Mellon history | 71.81K | $554.34K | 0.00% | Reduce |
| Charles Schwab Investment Management history | 67.27K | $519.29K | 0.00% | Add |
| Goldman Sachs Group history | 30.86K | $238.22K | 0.00% | Add |
| JPMorgan Chase & Co history | 30.03K | $232.00K | 0.00% | Add |
| Morgan Stanley history | 27.91K | $215.50K | 0.00% | Add |
| Bank of America Corp history | 23.50K | $181.42K | 0.00% | Reduce |
| Deutsche Bank AG history | 14.75K | $113.88K | 0.00% | Add |
| UBS Group AG history | 7.99K | $61.71K | 0.00% | Add |
| Wells Fargo & Co history | 4.39K | $33.91K | 0.00% | New |
| Legal & General Investment Management America history | 2.47K | $19.09K | 0.00% | Hold |
| Fidelity Management & Research (FMR) history | 1.26K | $9.70K | 0.00% | Add |
| Citigroup Inc history | 523 | $4.04K | 0.00% | Reduce |
| Renaissance Technologies history | 330.29K | $2.55K | 0.00% | Reduce |
| T. Rowe Price Associates history | 19.62K | $152 | 0.00% | Add |
Q4 2022 — 17 funds
| Fund | Shares | Value | Portfolio Weight | Change |
|---|---|---|---|---|
| Vanguard Group history | 1.36M | $10.00M | 0.00% | Add |
| Northern Trust Corp history | 191.57K | $1.41M | 0.00% | Add |
| BNY Mellon history | 83.59K | $614.39K | 0.00% | Add |
| Charles Schwab Investment Management history | 64.50K | $474.05K | 0.00% | Add |
| Goldman Sachs Group history | 30.49K | $224.09K | 0.00% | Add |
| Bank of America Corp history | 23.67K | $173.95K | 0.00% | Add |
| Citadel Advisors history | 22.40K | $164.67K | 0.00% | New |
| Morgan Stanley history | 17.56K | $129.07K | 0.00% | Add |
| Deutsche Bank AG history | 8.15K | $59.94K | 0.00% | Add |
| Legal & General Investment Management America history | 2.47K | $18.15K | 0.00% | Add |
| UBS Group AG history | 2.28K | $16.73K | 0.00% | New |
| Fidelity Management & Research (FMR) history | 680 | $5.00K | 0.00% | Add |
| Citigroup Inc history | 594 | $4.37K | 0.00% | Reduce |
| Geode Capital Management history | 485.75K | $3.57K | 0.00% | Add |
| Renaissance Technologies history | 332.89K | $2.45K | 0.00% | Reduce |
| T. Rowe Price Associates history | 19.40K | $143 | 0.00% | Add |
| JPMorgan Chase & Co history | 14.23K | $105 | 0.00% | Add |
New Positions (latest)
No fund opened a new position this quarter.
Fully Exited (vs previous quarter)
No tracked fund fully exited this quarter.
Fund Position History — shares by quarter (top 20 funds)
| Fund | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 | Q1 2022 | Q4 2021 | Q3 2021 | Q2 2021 | Q1 2021 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vanguard Group | 2.71M | 2.23M | 1.47M | 1.40M | 1.37M | 1.36M | 1.12M | 629.77K | 707.60K | 697.75K | 580.48K | 575.22K | 575.34K |
| Franklin Resources | 1.09M | 1.22M | — | — | — | — | — | — | — | — | — | — | — |
| Geode Capital Management | 910.60K | 764.35K | 628.92K | 617.97K | 556.21K | 485.75K | 251.50K | 247.99K | 215.16K | 196.67K | 194.02K | — | — |
| Morgan Stanley | 789.64K | 718.74K | 53.47K | 50.20K | 27.91K | 17.56K | 11.56K | 13.20K | 9.28K | 9.14K | 2.73K | — | — |
| Two Sigma Investments | 519.97K | 378.41K | 190.59K | 58.03K | — | — | 21.92K | 20.03K | 47.71K | 79.68K | 39.22K | — | — |
| Janus Henderson Group | 450.83K | 583.24K | — | — | — | — | — | — | — | — | — | — | — |
| D. E. Shaw & Co | 428.56K | 295.54K | 48.63K | — | — | — | — | — | — | — | — | — | — |
| Balyasny Asset Management | 373.00K | — | — | — | — | — | — | — | — | — | — | — | — |
| Northern Trust Corp | 341.70K | 296.69K | 270.42K | 257.52K | 193.99K | 191.57K | 124.48K | 125.77K | 101.71K | 105.59K | 107.23K | — | — |
| Charles Schwab Investment Management | 339.14K | 297.45K | 234.26K | 86.28K | 67.27K | 64.50K | 39.82K | 39.82K | 32.42K | 30.12K | 24.62K | — | — |
| BNY Mellon | 325.94K | 102.35K | 92.72K | 91.51K | 71.81K | 83.59K | 64.48K | 58.55K | 49.16K | 51.74K | 50.54K | — | — |
| Invesco Ltd | 272.63K | 241.78K | 217.14K | — | — | — | — | — | — | — | — | — | — |
| Goldman Sachs Group | 240.44K | 197.94K | 66.44K | 55.77K | 30.86K | 30.49K | 23.94K | 42.92K | 22.85K | 13.38K | — | — | — |
| Fidelity Management & Research (FMR) | 238.56K | 238.55K | 464.81K | 675.59K | 1.26K | 680 | 202 | 134 | 266 | — | — | — | — |
| Citadel Advisors | 215.48K | 882.86K | 29.87K | 56.02K | — | 22.40K | — | — | — | — | — | — | — |
| Citigroup Inc | 207.50K | 35.78K | 670 | 10.28K | 523 | 594 | 619 | 1.60K | 1.04K | 3.77K | 1.33K | — | — |
| Deutsche Bank AG | 204.48K | 129.48K | 17.51K | 127.33K | 14.75K | 8.15K | 8.05K | 9.09K | 6.30K | 7.04K | 6.68K | — | — |
| Bank of America Corp | 202.41K | 91.77K | 21.30K | 17.91K | 23.50K | 23.67K | 6.59K | 9.88K | 15.44K | 4.94K | 3.37K | — | — |
| Wellington Management Group | 161.15K | 109.88K | 39.73K | — | — | — | — | — | — | — | — | — | — |
| UBS Group AG | 153.47K | 65.81K | 19.05K | 45.85K | 7.99K | 2.28K | — | 1.20K | 2.37K | 5.00K | 1.14K | — | — |